INT169251

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.88
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Phox2b) DNA binding (Phox2b)
Anatomy Link Frequency
neurons 2
ganglia 2
brainstem 2
juvenile 1
hippocampus 1
Phox2b (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 4 99.02 Very High Very High Very High
Hippocampus 132 98.42 Very High Very High Very High
medulla 34 97.64 Very High Very High Very High
Dopamine 4 96.92 Very High Very High Very High
Pain 5 87.44 High High
anesthesia 4 84.72 Quite High
imagery 28 81.96 Quite High
Dorsal horn 4 67.52 Quite High
Spinal cord 8 66.00 Quite High
GABAergic 4 62.08 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 7 98.20 Very High Very High Very High
Ganglion Cysts 176 98.04 Very High Very High Very High
Injury 63 96.92 Very High Very High Very High
Syndrome 52 96.32 Very High Very High Very High
Central Hypoventilation Syndrome 162 91.56 High High
Frailty 4 90.88 High High
Targeted Disruption 13 89.32 High High
Sleep Disorders 6 74.64 Quite High
Hypoventilation 11 73.84 Quite High
Cognitive Disorder 18 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phox2a expression precedes Phox2b expression in the geniculate and petrosal ganglia.
Gene_expression (expression) of Phox2b in ganglia
1) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.17 Pain Relevance 0
Later in embryonic development (E16.5), co expression of Phox2a and Phox2b defines a population of neurons in the petrosal ganglion that expresses the dopamine-synthesizing enzyme, tyrosine hydroxylase (TH), in response to depolarizing stimuli [25].
Gene_expression (expression) of Phox2b in neurons associated with ganglion cysts and dopamine
2) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.10 Pain Relevance 0.05
Accordingly, Phox2a expression is dependent on Eya1, but is independent of Ngn2, and Phox2b expression is dependent on Ngn2 [11,19].
Gene_expression (expression) of Phox2b
3) Confidence 0.70 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.23 Pain Relevance 0.03
In addition to Phox2b, neurons of the NST also express another homeobox gene, Tlx3 [131].
Gene_expression (express) of Phox2b in neurons
4) Confidence 0.61 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.16
The mouse equivalent Phox2b transcription factor is expressed in the pyramidal and granule cell layers of the hippocampus [19], as well as the well-described targets in visceral ganglia and brainstem [38], [47].
Gene_expression (expressed) of Phox2b in ganglia associated with medulla and hippocampus
5) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713409 Disease Relevance 1.21 Pain Relevance 0.14
The hippocampus may also be affected by developmental consequences of PHOX2B mutations, since Phox2b expression in the mouse is found in pyramidal and granule cell layers of that structure [19].
Gene_expression (expression) of Phox2b in hippocampus associated with hippocampus
6) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713409 Disease Relevance 0.92 Pain Relevance 0.22
The pFRG neurons express the transcription factor Phox2b, display a pre-inspiratory discharge and play a major role in detecting CO2/pH changes and adjusting the RRG activity in neonatal and juvenile animals [3], [4].
Gene_expression (express) of Phox2b in juvenile
7) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.05 Pain Relevance 0.05
The mouse equivalent Phox2b transcription factor is expressed in the pyramidal and granule cell layers of the hippocampus [19], as well as the well-described targets in visceral ganglia and brainstem [38], [47].
Gene_expression (expressed) of Phox2b in brainstem associated with medulla and hippocampus
8) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713409 Disease Relevance 1.21 Pain Relevance 0.14
Here, we show that isoflurane causes robust activation of CO(2)/pH-sensitive, Phox2b-expressing neurons located in the retrotrapezoid nucleus (RTN) of the rodent brainstem, in vitro and in vivo.
Gene_expression (neurons) of Phox2b-expressing in brainstem associated with medulla and isoflurane
9) Confidence 0.05 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20610767 Disease Relevance 0 Pain Relevance 0.39

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