INT169300

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.15
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
synovial cells 1
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 57 100.00 Very High Very High Very High
agonist 18 100.00 Very High Very High Very High
qutenza 2 100.00 Very High Very High Very High
Cannabinoid 26 99.70 Very High Very High Very High
Osteoarthritis 89 97.16 Very High Very High Very High
rheumatoid arthritis 99 96.88 Very High Very High Very High
Endocannabinoid 76 91.12 High High
allodynia 19 86.48 High High
cytokine 22 85.88 High High
antagonist 27 85.36 High High
Disease Link Frequency Relevance Heat
Wound Healing 1 97.52 Very High Very High Very High
Frailty 90 97.16 Very High Very High Very High
Rheumatoid Arthritis 99 96.88 Very High Very High Very High
Injury 7 87.04 High High
Neuropathic Pain 25 86.48 High High
Disease 47 85.04 High High
Pain 27 80.84 Quite High
Nociception 9 79.24 Quite High
INFLAMMATION 44 73.16 Quite High
Cancer 45 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2 (for CB1IR) and < and ?
Phosphorylation (for) of CB1IR
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 0.15 Pain Relevance 0
Our pharmacological study demonstrating that the potent cannabinoid agonist HU210 phosphorylates ERK1 and ERK2 in fibroblast-like synovial cells in a PTX-dependent manner via the CB1 receptor lends further support to a functional role of this receptor system in OA and RA synovia.
Phosphorylation (phosphorylates) of CB1 receptor in synovial cells associated with cannabinoid, rheumatoid arthritis, agonist and osteoarthritis
2) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.22 Pain Relevance 1.08
Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.
Phosphorylation (phosphorylation) of CB1 associated with qutenza, cannabinoid receptor and agonist
3) Confidence 0.25 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.18 Pain Relevance 0.57
Together, this in vitro study and our current findings suggest a functional relationship between astrocytic cannabinoid receptor signaling and inhibition of p38 phosphorylation.
Phosphorylation (phosphorylation) of cannabinoid receptor associated with cannabinoid receptor
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.59 Pain Relevance 0.66

General Comments

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