INT169301

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.89
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GRAP2) endosome (GRAP2) nucleus (GRAP2)
cell-cell signaling (GRAP2) cytoplasm (GRAP2)
GRAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 97.00 Very High Very High Very High
Cannabinoid receptor 10 96.56 Very High Very High Very High
Spinal cord 36 95.60 Very High Very High Very High
qutenza 2 82.08 Quite High
agonist 22 80.52 Quite High
withdrawal 11 62.12 Quite High
Action potential 12 5.00 Very Low Very Low Very Low
Sciatic nerve 9 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 105 99.04 Very High Very High Very High
Reprotox - General 1 152 95.52 Very High Very High Very High
Diabetes Mellitus 36 91.92 High High
Wound Healing 7 91.40 High High
Prostate Cancer 12 88.64 High High
Injury 13 85.96 High High
Renal Insufficiency 4 84.88 Quite High
Obesity 18 77.40 Quite High
Osteoporosis 3 76.64 Quite High
Death 22 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both CAP and WIN induced transient increases in Erk1/2, p38, JNK1/2 MAPK and Akt/PI-3K phosphorylation status resulting in cell proliferation and migration increases which mirrored those elicited by EGF.
Phosphorylation (phosphorylation) of p38
1) Confidence 0.21 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.14 Pain Relevance 0.63
We studied the effects of goserelin incubation on two main MAPK-pathways (phos. p38 and phosphor ERK1/2) and on c-fos 24 h after start of incubation, 12 h after irradiation (to reflect long term effects).
Phosphorylation (phosphor) of p38
2) Confidence 0.18 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC2034383 Disease Relevance 0.37 Pain Relevance 0.06
Phosphorylated p38 was induced by goserelin incubation and irradiation in LNCaP cells.
Phosphorylation (Phosphorylated) of p38
3) Confidence 0.14 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC2034383 Disease Relevance 0.33 Pain Relevance 0
Downstream the LHRH receptor, changes in protein expression of c-fos, phosphorylated p38 and phosphorylated ERK1/2 were analyzed by means of Western blotting after incubation with goserelin and irradiation with 4 Gy.
Phosphorylation (phosphorylated) of p38
4) Confidence 0.14 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC2034383 Disease Relevance 0.48 Pain Relevance 0
Downstream the LHRH receptor, changes in protein expression of c-fos, phosphorylated p38 and phosphorylated ERK1/2 were analyzed by means of Western blotting after incubation with goserelin and irradiation with 4 Gy.
Phosphorylation (phosphorylated) of p38
5) Confidence 0.14 Published 2007 Journal Radiat Oncol Section Abstract Doc Link PMC2034383 Disease Relevance 0.48 Pain Relevance 0
De-ATSCs showed increased migration activity that mediated by P38/JUNK and ERK phosphorylation.
Phosphorylation (phosphorylation) of P38
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2817727 Disease Relevance 0.17 Pain Relevance 0.05
Collectively, hypoxia/DHP-d-induced Rex-1 expression was shown to be positively regulated by JAK/STAT3 and p38/MEK phosphorylation, and Rex-1 controlling hypoxia/DHP-d-induced cell proliferation and dedifferentiation (Figure 3).
Phosphorylation (phosphorylation) of p38 associated with hypoxia
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.48 Pain Relevance 0
function as paracrine growth factors, and induced active cell migration prominently involving the phosphorylation of MAPK cascade proteins, such as p38, ERK1/2, and JUNK (Figure 4).
Phosphorylation (phosphorylation) of p38
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.44 Pain Relevance 0

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