INT169323

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 4.09
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) extracellular region (Cxadr) cell adhesion (Cxadr)
mitochondrion organization (Cxadr) plasma membrane (Cxadr) nucleus (Cxadr)
Anatomy Link Frequency
CAR 7
kidney 7
alveolar cells 2
liver 1
cardiomyocytes 1
Cxadr (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 27 97.78 Very High Very High Very High
Demyelination 4 97.08 Very High Very High Very High
Substantia nigra 162 95.96 Very High Very High Very High
dorsal root ganglion 5 91.28 High High
Central nervous system 81 91.00 High High
isoflurane 11 90.48 High High
anesthesia 16 89.60 High High
Sciatic nerve 3 81.68 Quite High
Pain 1 80.40 Quite High
Spinal cord 1 79.60 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 282 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 36 99.98 Very High Very High Very High
Demyelinating Disease 4 97.08 Very High Very High Very High
Ganglion Cysts 6 91.28 High High
Parkinson's Disease 135 78.72 Quite High
Cytomegalovirus Infection 28 78.32 Quite High
Rabies Virus Infection 9 75.36 Quite High
Disease 18 74.16 Quite High
Heart Rate Under Development 5 70.00 Quite High
Neurodegenerative Disease 27 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased CXADR expression on the demyelinated axons facilitated axoplasmic viral entry.
Positive_regulation (Increased) of Gene_expression (expression) of CXADR
1) Confidence 0.67 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20623527 Disease Relevance 0.69 Pain Relevance 0.62
Here we achieved increased gene delivery by transgenic overexpression of CAR, a strategy that is suitable only for establishing proof-of-concept in animal models.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CAR in CAR associated with targeted disruption
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.17 Pain Relevance 0.15
In the context of the design of gene therapy strategies, induction of CAR expression is probably not feasible, but development of Ad viruses with modified tropism is a promising approach, and a search for Ad viruses which might interact with other proteins known to be at synaptic sites might prove fruitful.
Positive_regulation (induction) of Gene_expression (expression) of CAR in CAR
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.51 Pain Relevance 0.17
This indicates that CAR KO cardiomyocytes, unlike AV nodal cells are not limited by GAP junction activity, a feature which could derive both from altered expression of connexins and differential localization of CAR between the cell types (Fig. 3).
Positive_regulation (derive) of in CAR Gene_expression (expression) of CAR in cardiomyocytes associated with targeted disruption
4) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.95 Pain Relevance 0.04
Direct assessment of CAR protein in the ventral midbrain revealed that there is a relative paucity of CAR expression in this region in wild type animals, while nigral CAR expression is markedly increased in hCAR transgenic animals.
Positive_regulation (increased) of Gene_expression (expression) of CAR in CAR associated with targeted disruption and midbrain
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.33 Pain Relevance 0.27
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of Gene_expression (express) of CAR in kidney associated with targeted disruption
6) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in heart Gene_expression (express) of CAR in kidney associated with targeted disruption
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in lungs Gene_expression (express) of CAR in kidney associated with targeted disruption
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in liver Gene_expression (express) of CAR in kidney associated with targeted disruption
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in muscle Gene_expression (express) of CAR in kidney associated with targeted disruption
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in brain Gene_expression (express) of CAR in kidney associated with targeted disruption
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.25
Similar findings were observed with adenoviruses, and explained by an ARDS-induced exposure/expression of the CAR and integrin receptors that mediate adenoviral entry into the alveolar cells [14].
Positive_regulation (induced) of Gene_expression (expression) of CAR in alveolar cells associated with adult respiratory distress syndrome
12) Confidence 0.01 Published 2007 Journal Respir Res Section Body Doc Link PMC2238754 Disease Relevance 0.30 Pain Relevance 0

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