INT169336

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.31
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
blood 2
Jak2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 87 98.84 Very High Very High Very High
Arthritis 144 97.84 Very High Very High Very High
rheumatoid arthritis 66 86.24 High High
spinal inflammation 1 75.00 Quite High
Inflammation 64 72.32 Quite High
Potency 78 68.56 Quite High
psoriasis 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 156 97.84 Very High Very High Very High
Rheumatoid Arthritis 66 86.24 High High
Low Back Pain 1 75.00 Quite High
Inflammatory Bowel Disease 1 72.88 Quite High
Hematological Disease 12 65.52 Quite High
Disease 30 64.12 Quite High
INFLAMMATION 60 60.52 Quite High
Hepatocellular Cancer 3 51.92 Quite High
Reprotox - General 1 3 50.28 Quite High
Neutropenia 3 39.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we first demonstrated the association of JAK2 polymorphisms with the susceptibility of AS, which indicated that IL-23 pathway also was an important etiological factor in AS in Chinese population.
JAK2 Binding (association) of
1) Confidence 0.42 Published 2010 Journal Clin. Immunol. Section Abstract Doc Link 20627814 Disease Relevance 0.15 Pain Relevance 0.11
Although we did not directly evaluate inhibition of JAK2 or in vitro granulopoiesis in the rat, inhibition of arthritis, cytokines and neutrophilia in the AIA model were observed at plasma exposures that were well below the human JAK2 IC50 and effects on GM-CSF stimulated STAT phosphorylation in the rat whole blood assay.
JAK2 Neg (inhibition) Binding (inhibition) of in blood associated with cytokine and arthritis
2) Confidence 0.30 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.73 Pain Relevance 0.42
The concentrations at which CP-690,550 is shown to have an effect on hematopoietic stem cell colony formation and differentiation in vitro correlated well with human in vitro selectivity data and JAK 2 inhibition (Table 1, human whole blood cytokine signaling assays).
JAK 2 Binding (inhibition) of in blood associated with cytokine
3) Confidence 0.30 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.10 Pain Relevance 0.14
In a recent analysis of kinase inhibitor selectivity within the human kinome, CP-690,550 was found to be highly selective for the JAK family kinases, and to have similar binding affinities for both JAK2 and JAK3 [22].
JAK2 Binding (affinities) of
4) Confidence 0.29 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.33 Pain Relevance 0.26

General Comments

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