INT169344

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.34
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dynll1) transport (Dynll1) mitochondrion (Dynll1)
cytoskeleton (Dynll1) nucleus (Dynll1) enzyme binding (Dynll1)
Anatomy Link Frequency
neuronal 4
proximal 4
Dynll1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 14 100.00 Very High Very High Very High
Triptan 24 99.58 Very High Very High Very High
Sciatic nerve 30 94.16 High High
allodynia 8 91.72 High High
Sumatriptan 2 89.48 High High
headache 8 87.68 High High
trigeminal ganglion 6 75.20 Quite High
Migraine 6 75.00 Quite High
calcitonin gene related peptide 2 57.20 Quite High
cytokine 4 25.44 Quite Low
Disease Link Frequency Relevance Heat
Stress 6 96.76 Very High Very High Very High
Nervous System Injury 14 94.44 High High
Neuropathic Pain 10 91.72 High High
Ganglion Cysts 8 91.68 High High
Hypersensitivity 2 85.92 High High
Headache 14 75.00 Quite High
Injury 14 60.44 Quite High
Syndrome 2 60.00 Quite High
Neurological Disease 2 38.48 Quite Low
Wallerian Degeneration 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Triptan administration thus promotes increased expression of neuronal nitric oxide synthase in dural afferents, which is critical for enhanced sensitivity to environmental stress.
Positive_regulation (promotes) of Gene_expression (expression) of neuronal nitric oxide synthase in neuronal associated with stress, triptan and neuronal nitric oxide synthase
1) Confidence 0.49 Published 2010 Journal Brain Section Abstract Doc Link 20627971 Disease Relevance 0.93 Pain Relevance 1.70
Triptan administration thus promotes increased expression of neuronal nitric oxide synthase in dural afferents, which is critical for enhanced sensitivity to environmental stress.
Positive_regulation (increased) of Gene_expression (expression) of neuronal nitric oxide synthase in neuronal associated with stress, triptan and neuronal nitric oxide synthase
2) Confidence 0.49 Published 2010 Journal Brain Section Abstract Doc Link 20627971 Disease Relevance 0.92 Pain Relevance 1.69
Interrupted anterograde axonal transport at the crush site resulting in the accumulation of ERK-P in the proximal nerve segment may account for the earlier increase in the expression of ERK-P in this part at post-crush day 1 than in the DRG (7 days).
Positive_regulation (increase) of Gene_expression (expression) of P in in proximal
3) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.24 Pain Relevance 0.05
Interrupted anterograde axonal transport at the crush site resulting in the accumulation of ERK-P in the proximal nerve segment may account for the earlier increase in the expression of ERK-P in this part at post-crush day 1 than in the DRG (7 days).
Spec (may) Positive_regulation (account) of Gene_expression (expression) of P in in proximal
4) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.25 Pain Relevance 0.05

General Comments

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