INT169350

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.25
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ksr1) kinase activity (Ksr1) cytoplasm (Ksr1)
Anatomy Link Frequency
hepatocytes 2
Ksr1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 99.34 Very High Very High Very High
Paracetamol 1 89.12 High High
cytokine 1 75.04 Quite High
Disease Link Frequency Relevance Heat
Toxicity 1 97.00 Very High Very High Very High
Apoptosis 3 96.96 Very High Very High Very High
Targeted Disruption 1 94.84 High High
Hepatotoxicity 1 89.40 High High
Liver Failure 2 87.36 High High
Hepatitis 4 87.00 High High
Stress 2 76.16 Quite High
Death 3 72.96 Quite High
Disease 1 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of Timp3 enhanced metalloproteinase-dependent EGFR signaling due to increased release of the EGFR ligands TGF-alpha, amphiregulin, and HB-EGF, while depletion of shed amphiregulin resensitized Timp3-/- hepatocytes to apoptosis.
Positive_regulation (increased) of Localization (release) of HB-EGF in hepatocytes associated with metalloproteinase and apoptosis
1) Confidence 0.03 Published 2010 Journal J. Clin. Invest. Section Abstract Doc Link 20628198 Disease Relevance 1.25 Pain Relevance 0.28

General Comments

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