INT169400

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) extracellular space (Il1b) aging (Il1b)
extracellular region (Il1b) nucleus (IRF6) DNA binding (IRF6)
Anatomy Link Frequency
blood 3
IRF6 (Homo sapiens)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 4 95.40 Very High Very High Very High
rheumatoid arthritis 1 94.20 High High
Analgesic 1 83.16 Quite High
Pain 1 81.28 Quite High
cytokine 5 77.64 Quite High
Disease Link Frequency Relevance Heat
Arthritis 5 95.40 Very High Very High Very High
Rheumatoid Arthritis 1 94.20 High High
Pain 1 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among them, compound 4a, (S)-2-(4-fluorophenyl)-4-(1,2,3,5,6,8a-hexahydroindolizin-7-yl)-3-(pyridin-4-yl)-1H-pyrrole (R-132811), achieved the most promising results in various in vitro and in vivo tests including several rheumatoid arthritis models ((i) inhibition of p38alpha, p38beta, p38gamma, and p38delta MAP kinases: IC(50)=0.034, 0.572, >10, and >10 microM, respectively; (ii) inhibition of TNFalpha, IL-1beta, IL-6, and IL-8 production in human whole blood: IC(50)=0.026, 0.020, 0.88, and 0.016 microM, respectively; (iii) inhibition of LPS induced TNFalpha, IL-1beta and IL-6 production in mice: ID(50)=0.93, 8.63, and 0.11 mg/kg, p.o., respectively; (iv) inhibition of anti-collagen antibody-induced arthritis in mice: ID(50)=2.22 mg/kg, p.o.; (v) inhibition of collagen-induced arthritis in mice: ID(50)=2.38 mg/kg, p.o.; (vi) prophylactic effect on adjuvant-induced arthritis in rats: ID(50)=3.1 mg/kg, p.o.; (vii) therapeutic effect on adjuvant-induced arthritis in rats: ID(50)=4.9 mg/kg, p.o.; (viii) analgesic effect on adjuvant-induced arthritic pain in rats: ID(50)=2.9 mg/kg, p.o.).
Negative_regulation (inhibition) of LPS in blood Positive_regulation (induced) of Gene_expression (production) of IL-1beta in blood associated with pain, analgesic, rheumatoid arthritis and arthritis
1) Confidence 0.50 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20637613 Disease Relevance 0.62 Pain Relevance 0.50

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