INT169402

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 27
Disease Relevance 5.13
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
filaments 3
neuron 2
growth cone 1
Trpv4 (Rattus norvegicus)
Trpv4 - P19S (2)
Pain Link Frequency Relevance Heat
agonist 120 99.76 Very High Very High Very High
qutenza 2 99.16 Very High Very High Very High
Taxol 600 98.60 Very High Very High Very High
peripheral neuropathy 20 93.92 High High
imagery 240 93.56 High High
Pain 260 93.04 High High
TRP channel 20 93.04 High High
Hyperalgesia 85 92.84 High High
Mechanosensation 60 89.60 High High
dorsal root ganglion 320 88.96 High High
Disease Link Frequency Relevance Heat
Asthma 14 99.32 Very High Very High Very High
Nociception 280 98.16 Very High Very High Very High
Respiratory Sounds 4 96.52 Very High Very High Very High
Pulmonary Disease 2 94.32 High High
Peripheral Neuropathy 20 93.92 High High
Hyperalgesia 85 92.84 High High
Pain 240 92.24 High High
Occupational Lung Diseases 2 90.48 High High
Hypersensitivity 2 89.88 High High
Adhesions 60 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functional interaction of TRPV4 and the cytoskeleton is mutual as Taxol, a microtubule stabilizer, reduces the Ca2+-influx via TRPV4.


TRPV4 Binding (interaction) of associated with taxol
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2906515 Disease Relevance 0.12 Pain Relevance 0.14
Next we addressed whether TRPV4 can also bind to polymerized filaments.
TRPV4 Binding (bind) of in filaments
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.03
We investigated the interaction of TRPV4 with cytoskeletal components biochemically, cell biologically by observing morphological changes of DRG-neurons and DRG-neuron-derived F-11 cells, as well as functionally with calcium imaging.
TRPV4 Binding (interaction) of in neuron associated with imagery
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2906515 Disease Relevance 0.17 Pain Relevance 0.14
If the N-terminal cytoplasmic domain of TRPV4 can also interact with the cytoskeleton has not been established yet.
TRPV4 Binding (interact) of
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.20 Pain Relevance 0.06
Here we probed if the MBP-TRPV4-Ct can also interact with polymerized microtubules.
TRPV4 Binding (interact) of
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.05
The interaction with TRPV4 stabilizes microtubules even under depolymerizing conditions in vitro.
TRPV4 Binding (interaction) of
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2906515 Disease Relevance 0.16 Pain Relevance 0.14
These results confirm that MBP-TRPV4-Ct directly interacts with filamentous microtubules.
TRPV4 Binding (interacts) of
7) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.04
For experiments aimed at understanding the association of TRPV4-Ct with polymerised actin filaments, purified MBP-TRPV4-Ct alone was subjected to centrifugation at 70000 g/30 min/4°C to exclude any aggregates.
TRPV4 Binding (association) of in filaments
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.05
The interaction with TRPV4 stabilizes microtubules even under depolymerizing conditions in vitro.
TRPV4 Binding (interaction) of
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0.07 Pain Relevance 0
Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells.
TRPV4 Binding (interaction) of
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Title Doc Link 20657843 Disease Relevance 0 Pain Relevance 0.09
The functional interaction of TRPV4 and the cytoskeleton is mutual as Taxol, a microtubule stabilizer, reduces the Ca2+-influx via TRPV4.
TRPV4 Binding (interaction) of
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0.05 Pain Relevance 0
METHODOLOGY AND PRINCIPAL FINDINGS: We investigated the interaction of TRPV4 with cytoskeletal components biochemically, cell biologically by observing morphological changes of DRG-neurons and DRG-neuron-derived F-11 cells, as well as functionally with calcium imaging.
TRPV4 Binding (interaction) of in neuron
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link 20657843 Disease Relevance 0.09 Pain Relevance 0
The C-terminus of TRPV4 is sufficient for the direct interaction with tubulin and actin, both with their soluble and their polymeric forms.
TRPV4 Binding (interaction) of
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2906515 Disease Relevance 0.18 Pain Relevance 0.12
As TRPV4 modulates actin as well as microtubule stability, it has the ability to steer growth cone movements.
TRPV4 Binding (stability) of in growth cone
14) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.07 Pain Relevance 0.04
The C-terminus of TRPV4 interacts directly with actin and microtubule cytoskeletal components
TRPV4 Binding (interacts) of
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.44 Pain Relevance 0.20
According to this structure, the C-terminus of TRPV4 is exposed outside and accessible for interaction with other proteins.
TRPV4 Binding (interaction) of
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.09 Pain Relevance 0
Based on our previous experiments done on TRPV1 and the sequence homology between TRPV1 and TRPV4, we predicted that TRPV4 might interact with tubulin via its C-terminal domain.
TRPV4 Spec (might) Binding (interact) of
17) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0.29
Our findings suggest that the direct interaction of TRPV4 and actin is a general feature observed in various cellular systems.
TRPV4 Binding (interaction) of
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.15 Pain Relevance 0
MBP-TRPV4-Ct interacts with polymerized actin and tubulin filaments and favours formation of stable microtubules
TRPV4 Binding (favours) of in filaments
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.03
In experiments aiming to activated TRPV4, its agonist 4 ?
TRPV4 Binding (aiming) of associated with agonist
20) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.18

General Comments

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