INT169428

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
Anatomy Link Frequency
RT4 2
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 98.16 Very High Very High Very High
withdrawal 8 89.84 High High
qutenza 3 50.00 Quite Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 16 98.16 Very High Very High Very High
Hepatocellular Cancer 22 97.28 Very High Very High Very High
Cancer 68 94.96 High High
Apoptosis 47 89.76 High High
Stress 8 88.16 High High
Death 8 80.80 Quite High
Aging 1 63.16 Quite High
Glioma 27 50.00 Quite Low
Colon Cancer 27 50.00 Quite Low
Bladder Cancer 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pre-treatment of cells with CQ inhibited the down-regulation of p21Cip1 and p27Kip1 expressions induced by 5-FU and, on the other hand, inhibited the up-regulation of the expression of CDK2.
Regulation (regulation) of Gene_expression (expression) of CDK2
1) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43].
Regulation (effected) of Gene_expression (expression) of Cdk2
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: Capsaicin induces the cell cycle arrest of bladder cancer RT4 cells G(0)/G(1) phase and growth inhibition via TRPV1 receptor by modulating the expression of P53, P21 and CDK2.


Regulation (modulating) of Gene_expression (expression) of CDK2 in RT4
3) Confidence 0.17 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20646592 Disease Relevance 0 Pain Relevance 0
Furthermore, we showed the abnormal expression of cyclin E and CDK2 in HR group which could be associated to the inflammatory process [16].


Regulation (abnormal) of Gene_expression (expression) of CDK2 associated with inflammation
4) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.96 Pain Relevance 0.09

General Comments

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