INT169431

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 21.76
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vps54) growth (Vps54)
Anatomy Link Frequency
liver 1
endothelial cells 1
vessels 1
Vps54 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 141 99.98 Very High Very High Very High
positron emission tomography 370 93.84 High High
Inflammation 69 74.48 Quite High
chemokine 3 59.24 Quite High
cytokine 40 34.20 Quite Low
imagery 190 9.72 Low Low
metalloproteinase 33 7.60 Low Low
anesthesia 33 5.00 Very Low Very Low Very Low
isoflurane 30 5.00 Very Low Very Low Very Low
ketamine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 1212 100.00 Very High Very High Very High
Cancer 851 100.00 Very High Very High Very High
Metastasis 186 100.00 Very High Very High Very High
Glioblastoma 6 97.88 Very High Very High Very High
Malignant Neoplastic Disease 22 95.92 Very High Very High Very High
Cirrhosis 52 95.20 Very High Very High Very High
Pressure And Volume Under Development 70 95.12 Very High Very High Very High
Disease 36 95.00 High High
Liver Cancer 21 90.28 High High
Glioma 3 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Gene analysis showed that for different gene expression among groups, the density of gene net in palliative group (B, 0.0670) were higher than those in control groups (A, 0.0145; C1, 0.0210; C2, 0.0146), the condensation degree of gene net in residual HCC (B, 0.1940) was higher than that in its own control group (A, 0.0098).
Gene_expression (residual) of HCC
1) Confidence 0.21 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20646604 Disease Relevance 0 Pain Relevance 0
In poorly differentiated HCC, VEGF protein is expressed by the endothelial cells lining intratumoral vessels.
Gene_expression (expressed) of HCC in vessels associated with hepatocellular cancer
2) Confidence 0.11 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.78 Pain Relevance 0
Hence, by combining the use of bioimaging techniques as well as histological analysis, we have shown that the combined RAPA/BEV chemotherapy is effective against HCC xenograft in the murine model.


Gene_expression (effective) of HCC associated with hepatocellular cancer
3) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.93 Pain Relevance 0
All these results further strengthened our hypothesis that combined RAPA/BEV is effective in preventing HCC progression.
Gene_expression (progression) of HCC associated with hepatocellular cancer
4) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.20 Pain Relevance 0.05
Although mice treated with either single agent did not exhibit advanced HCC, they nonetheless displayed “patchy” strong expression of VEGF, especially in mice treated with RAPA only.
Neg (not) Gene_expression (exhibit) of HCC associated with hepatocellular cancer
5) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.25 Pain Relevance 0.04
Our immunohistochemistry staining of VEGF showed that only the vehicle control mice eventually developed advanced HCC characterized by poorly differentiated HCC tissues surrounded by well-differentiated HCC tissues.
Gene_expression (tissues) of HCC associated with hepatocellular cancer
6) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.31 Pain Relevance 0.03
Currently, alpha-fetoprotein (AFP) is the only serological marker that is available for the detection of HCC clinically.
Gene_expression (detection) of HCC associated with hepatocellular cancer
7) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.04 Pain Relevance 0.04
Our immunohistochemistry staining of VEGF showed that only the vehicle control mice eventually developed advanced HCC characterized by poorly differentiated HCC tissues surrounded by well-differentiated HCC tissues.
Gene_expression (tissues) of HCC associated with hepatocellular cancer
8) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.26 Pain Relevance 0.03
In a study by Giannelli et al. [34], only a small percentage of patients showed AFP values that are reflective of HCC.
Gene_expression (reflective) of HCC associated with hepatocellular cancer
9) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.91 Pain Relevance 0.12
As such, the use of a combined RAPA/BEV might provide a potent antiangiogenic therapy for retardation of HCC progression.
Gene_expression (progression) of HCC associated with hepatocellular cancer
10) Confidence 0.08 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.21 Pain Relevance 0
We speculate that besides suppressing VEGF expression from HCC tumor cells, rapamycin might possibly inhibit proliferation of endothelial cells and blocked angiogenesis.
Gene_expression (expression) of HCC in endothelial cells associated with cancer and hepatocellular cancer
11) Confidence 0.07 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.17 Pain Relevance 0
The current study found that coronin-1C expression in HCC nude mice models was correlated to the aggressive and metastastic behaviors of HCC.
Gene_expression (expression) of HCC associated with hepatocellular cancer
12) Confidence 0.05 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845108 Disease Relevance 1.16 Pain Relevance 0
In the first experiment, 48 nude mice bearing HCC xenografts were randomized into two groups 14 days after orthotopic implantation (24 mice/group), including a palliative resection group of mice undergoing partial HCC resection with preservation of 2 mm tumor [17] and a sham operation group (control) of mice having only exposure of the liver but no resection.
Spec (partial) Gene_expression (resection) of HCC in liver associated with cancer, hepatocellular cancer and palliative
13) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.62 Pain Relevance 0.25
In most studies, palliative resection for HCC was combined with chemotherapy or biotherapy, such as IFN-?
Gene_expression (resection) of HCC associated with hepatocellular cancer and palliative
14) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.16 Pain Relevance 0.31
Coronin-1C expression in HCC specimens
Gene_expression (expression) of HCC associated with hepatocellular cancer
15) Confidence 0.05 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845108 Disease Relevance 1.68 Pain Relevance 0
We had investigated the relationship between cronin-1C expression and tumor spontaneous pulmonary metastasis in nude mice model of HCC.
Gene_expression (expression) of HCC associated with cancer, hepatocellular cancer and metastasis
16) Confidence 0.05 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845108 Disease Relevance 1.66 Pain Relevance 0
Human HCC tumor models produced by MHCC97H were established in nude mice by orthotopic inoculation, as described previously [15].
Gene_expression (produced) of HCC associated with cancer and hepatocellular cancer
17) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.99 Pain Relevance 0
Thus, JNK1 is required for efficient HCC induction in response to DEN administration [4].
Gene_expression (induction) of HCC associated with hepatocellular cancer
18) Confidence 0.03 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.83 Pain Relevance 0
-deficient mice, and the results showed that JNK1 is a critical factor for the increased incidence of HCC in Ikk?
Gene_expression (incidence) of HCC associated with hepatocellular cancer
19) Confidence 0.03 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.93 Pain Relevance 0.06
B and the JNK pathways in HCC development in this paper.

2.

Gene_expression (development) of HCC associated with hepatocellular cancer
20) Confidence 0.03 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.66 Pain Relevance 0.04

General Comments

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