INT169432

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 13.96
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vps54) growth (Vps54)
Vps54 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 8 92.88 High High
alcohol 17 91.56 High High
Inflammation 92 86.84 High High
chemokine 4 83.24 Quite High
positron emission tomography 111 75.68 Quite High
palliative 5 63.28 Quite High
fibrosis 16 62.52 Quite High
Inflammatory response 4 23.04 Low Low
cytokine 43 19.04 Low Low
imagery 57 9.36 Low Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 558 100.00 Very High Very High Very High
Hepatitis C Virus Infection 32 99.80 Very High Very High Very High
Hepatitis 46 99.74 Very High Very High Very High
Cirrhosis 28 99.68 Very High Very High Very High
Hepatitis B Virus Infection 37 99.66 Very High Very High Very High
Targeted Disruption 142 98.88 Very High Very High Very High
Infection 22 98.72 Very High Very High Very High
Colon Cancer 3 98.16 Very High Very High Very High
Liver Cancer 62 97.84 Very High Very High Very High
Injury 21 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The methods of support vector machine (SVM), gene significance analysis and gene correlation degree analysis were used to search the markers capable of differentiating the metastatic potential of HCC.
Positive_regulation (potential) of HCC
1) Confidence 0.16 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20646604 Disease Relevance 0.07 Pain Relevance 0
Moreover, its level varies between ethnic groups and is also not recommended for diagnosis of HCC in non-cirrhotic patients [35, 36].
Neg (not) Positive_regulation (recommended) of HCC associated with cirrhosis and hepatocellular cancer
2) Confidence 0.06 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.93 Pain Relevance 0.06
Although mice treated with either single agent did not exhibit advanced HCC, they nonetheless displayed “patchy” strong expression of VEGF, especially in mice treated with RAPA only.
Neg (not) Positive_regulation (advanced) of HCC associated with hepatocellular cancer
3) Confidence 0.06 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.24 Pain Relevance 0.04
However, its effect in HCC is less conclusively documented.
Positive_regulation (effect) of HCC associated with hepatocellular cancer
4) Confidence 0.06 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.87 Pain Relevance 0.06
Among them, particular HBV or HCV proteins induce HCC without other oncogenic alterations in mouse models [2].
Positive_regulation (induce) of HCC associated with hepatocellular cancer, hepatitis b virus infection and hepatitis c virus infection
5) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.86 Pain Relevance 0.03
Approximately, 70% of HCC tissues, but not background tissues, show positive immunostaining for phosphorylated JNK, suggesting that JNK is frequently active in human HCC [65].
Positive_regulation (active) of HCC associated with hepatocellular cancer
6) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.03 Pain Relevance 0.09
Thus, JNK1 is required for efficient HCC induction in response to DEN administration [4].
Positive_regulation (induction) of HCC associated with hepatocellular cancer
7) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.83 Pain Relevance 0
In a mouse model, the cell-permeable JIP peptide, which interferes with the interaction between JIP and JNK to inhibit JNK activity, suppresses chemically induced HCC [59].


Positive_regulation (induced) of HCC associated with hepatocellular cancer
8) Confidence 0.02 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.86 Pain Relevance 0.15
These results highlight that the activation of MYC alone is not sufficient to induce HCC.
Positive_regulation (induce) of HCC associated with hepatocellular cancer
9) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.07 Pain Relevance 0
Hepatitis B infection acquired during neonatal development versus adulthood results in a several-magnitude increased risk of HCC (Chang et al. 1991).
Positive_regulation (increased) of HCC associated with hepatocellular cancer, hepatitis b virus infection and infection
10) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.59 Pain Relevance 0.04
Carcinogen-induced HCC in Wistar rats is associated with MYC amplification and overexpression (De Miglio et al. 1999).
Positive_regulation (induced) of HCC associated with hepatocellular cancer
11) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.17 Pain Relevance 0
To investigate if MYC overexpression is sufficient to induce HCC in our model system, we removed doxycycline treatment in adult mice (6–12 weeks of age) transgenic for both TRE-MYC and LAP-tTA.
Positive_regulation (induce) of HCC associated with targeted disruption and hepatocellular cancer
12) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.90 Pain Relevance 0
Interestingly, the ability of these carcinogens, such as the hepatitis viruses, to induce HCC depends on the host age during infection.
Positive_regulation (induce) of HCC associated with hepatocellular cancer, infection and hepatitis
13) Confidence 0.02 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.54 Pain Relevance 0.05

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