INT169435

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 10.04
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CHPT1) lipid metabolic process (CHPT1)
Anatomy Link Frequency
amygdala 4
Tear 2
coronary artery 1
blood 1
colon 1
CHPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 396 100.00 Very High Very High Very High
Pain threshold 134 100.00 Very High Very High Very High
cOX1 4 100.00 Very High Very High Very High
Hyperalgesia 92 99.58 Very High Very High Very High
amygdala 486 99.20 Very High Very High Very High
unmyelinated 20 98.96 Very High Very High Very High
Inflammation 166 98.72 Very High Very High Very High
qutenza 2 98.26 Very High Very High Very High
c fibre 46 93.92 High High
anesthesia 3 89.44 High High
Disease Link Frequency Relevance Heat
Pain 395 100.00 Very High Very High Very High
Hyperalgesia 140 99.58 Very High Very High Very High
Hypersensitivity 114 99.58 Very High Very High Very High
Reflex Sympathetic Dystrophy 528 99.52 Very High Very High Very High
Colon Cancer 12 99.36 Very High Very High Very High
Metastasis 18 99.04 Very High Very High Very High
INFLAMMATION 135 98.72 Very High Very High Very High
Conjunctivitis 12 98.32 Very High Very High Very High
Increased Venous Pressure Under Development 57 97.04 Very High Very High Very High
Vomiting 1 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epicardial coronary artery diameter during the CPT is expressed as an average of the measurements between 30 and 180 s and flow velocity as an average of the measurements between 10 and 150 s after placing the hand into the cold water.
Gene_expression (expressed) of CPT in coronary artery
1) Confidence 0.61 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2427009 Disease Relevance 0 Pain Relevance 0.08
After 7 courses, because of serum CEA elevation, bi-weekly CPT-11/CDDP therapy (CPT-11 60 mg/m2, CDDP 30 mg/m2) was administered followed by weekly PTX therapy (65 mg/m2 day 1, 7, 14; total of 4 weeks).
Gene_expression (therapy) of CPT-11
2) Confidence 0.59 Published 2010 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 20647726 Disease Relevance 1.02 Pain Relevance 0.10
In other words, we observed lower amygdala activation when subjects were actively engaged in the CPT compared to when they passively waited for the same thermal stimuli (Fig. 1B).
Gene_expression (engaged) of CPT in amygdala associated with amygdala
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.09 Pain Relevance 0.57
In the first model, the following regressors were used: 1) +CPT heat anticipation, i.e., anticipation of painful heat while subjects were engaged in the CPT; 2) ?
Gene_expression (engaged) of CPT associated with pain
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.25 Pain Relevance 0.24
CPT versus anticipation of heat +CPT, i.e., to directly examine the degree to which engagement in the CPT affected amygdala activity during aversive anticipation; 2) anticipation of heat +CPT/RT versus anticipation of heat ?
Spec (examine) Gene_expression (examine) of CPT in amygdala associated with amygdala
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0 Pain Relevance 0.32
As hypothesized, a significant increase in bilateral amygdala activity was observed during anticipation of painfully hot stimulus in the -CPT condition compared to anticipation of equally painful stimulus in the +CPT condition (Fig. 1B) (right: 23/-8/-8; t(15)?
Gene_expression (condition) of CPT in amygdala associated with pain and amygdala
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.07 Pain Relevance 0.53
Furthermore, amygdala activation was significantly greater during the +CPT relative to +CPT/RT conditions (Fig. 1C - insert) (right: 29/-5/-13; t(15)?
Gene_expression (relative) of CPT in amygdala associated with amygdala
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.08 Pain Relevance 0.54
In the first model, the following regressors were used: 1) +CPT heat anticipation, i.e., anticipation of painful heat while subjects were engaged in the CPT; 2) ?
Gene_expression (engaged) of CPT associated with pain
8) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.25 Pain Relevance 0.21
As the criterion blood lead level increased from IBL20 through IBL60, so did the percentage of CPT2000 variance explained, with ?
Gene_expression (variance) of CPT2000 in blood
9) Confidence 0.48 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1314913 Disease Relevance 0 Pain Relevance 0.08
Capsaicin, a topical drug for pain relief that affects small nerve fibers, was found to elevate CPT thresholds for small myelinated and unmyelinated nerve fibers but not for large myelinated nerve fibers (Kiso et al. 2001).
Gene_expression (thresholds) of CPT in nerve associated with pain, qutenza and unmyelinated
10) Confidence 0.48 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1314913 Disease Relevance 0.61 Pain Relevance 0.42
Effects of green odor on CPT-induced cardiovascular responses
Gene_expression (responses) of CPT-induced
11) Confidence 0.43 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2259378 Disease Relevance 0 Pain Relevance 0
The induction of CPT1, CD36, COX1 and AngPL-4 expression by palmitate was not influenced by acylcarnitines (Fig. 5B–E), while acylcarnitines alone decreased AngPL-4 expression (Fig. 5E).
Gene_expression (expression) of CPT1 associated with cox1
12) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902514 Disease Relevance 0 Pain Relevance 0.09
For detection of CPT and HPT the patients pressed the button to indicate the onset of cold pain or heat pain.
Gene_expression (detection) of CPT associated with pain and pain threshold
13) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 1.21 Pain Relevance 1.05
PHS+ patients displayed significantly more cold pain hyperalgesia than PHS– patients (mean CPT: 21.24±1.55°C vs. 16.31±1.73°C, p<0.05), but no difference in e.g. heat hyperalgesia (mean HPT: 43.28±0.75°C vs. 42.44±1.11°C, p?
Gene_expression (mean) of CPT associated with pain, pain threshold and hyperalgesia
14) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 1.15 Pain Relevance 0.80
PHS+ patients displayed significantly more cold pain hyperalgesia than PHS– patients (mean CPT: 21.24±1.55°C vs. 16.31±1.73°C, p<0.05), but no difference in e.g. heat hyperalgesia (mean HPT: 43.28±0.75°C vs. 42.44±1.11°C, p?
Gene_expression (16.31) of CPT associated with pain, pain threshold and hyperalgesia
15) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 1.16 Pain Relevance 0.80
The hypothesis of cold pain hyperalgesia being caused by a combination of inflammation and A-delta-fibre degeneration is emphasised by the incomplete recovery of CPT in chronic CRPS.
Gene_expression (recovery) of CPT associated with pain, pain threshold, hyperalgesia, reflex sympathetic dystrophy and inflammation
16) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 1.87 Pain Relevance 1.37
A case of bone metastasis of colon cancer that markedly responded to S-1/CPT-11 combination chemotherapy and became curable by resection

Background

Gene_expression (chemotherapy) of CPT-11 in colon associated with colon cancer and metastasis
17) Confidence 0.23 Published 2006 Journal World J Surg Oncol Section Title Doc Link PMC1395313 Disease Relevance 0.68 Pain Relevance 0
Tear samples were collected in allergic patients 1 h before CPT and 10 min following a positive CPT response, and in healthy subjects after the highest provocation dose [27].
Gene_expression (response) of CPT in Tear associated with hypersensitivity
18) Confidence 0.09 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.43 Pain Relevance 0.09
When a total CPT score ?
Gene_expression (score) of CPT
19) Confidence 0.09 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.73 Pain Relevance 0
Tear samples were collected in allergic patients 1 h before CPT and 10 min following a positive CPT response, and in healthy subjects after the highest provocation dose [27].
Gene_expression (response) of CPT in Tear associated with hypersensitivity
20) Confidence 0.09 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.44 Pain Relevance 0.09

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