INT169454

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.51
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATD (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor antagonist 1 99.88 Very High Very High Very High
rheumatoid arthritis 50 99.80 Very High Very High Very High
ischemia 1 98.64 Very High Very High Very High
Neuropathic pain 1 98.24 Very High Very High Very High
Glutamate receptor 4 85.76 High High
Potency 1 81.64 Quite High
agonist 1 81.32 Quite High
Inflammation 5 70.68 Quite High
Multiple sclerosis 48 54.16 Quite High
spinal inflammation 25 22.12 Low Low
Disease Link Frequency Relevance Heat
Thyroid Disease 34 100.00 Very High Very High Very High
Rheumatoid Arthritis 57 99.80 Very High Very High Very High
Cv Unclassified Under Development 1 98.64 Very High Very High Very High
Neuropathic Pain 1 98.24 Very High Very High Very High
Disease 148 96.88 Very High Very High Very High
Genetic Predisposition To Disease 2 95.04 Very High Very High Very High
Congenital Anomalies 1 91.44 High High
Exophthalmos 1 76.84 Quite High
Pressure And Volume Under Development 1 76.28 Quite High
Arthritis 1 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Toward this end, NMDA receptor antagonists that interact with the GluN2B ATD show promise in animal models of ischemia, neuropathic pain, and Parkinson's disease.
ATD Binding (interact) of associated with nmda receptor antagonist, ischemia, neuropathic pain and disease
1) Confidence 0.21 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20660085 Disease Relevance 0.29 Pain Relevance 0.43
We find a set of SNPs which are strongly associated with both ATD and RA but when we look at the allele-specific genotype counts for these loci, we see that while one of the alleles is more common in RA patients, the other is more common in ATD patients.
ATD Binding (associated) of associated with thyroid disease and rheumatoid arthritis
2) Confidence 0.21 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 2.22 Pain Relevance 0.43

General Comments

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