INT169467

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.65
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Spink3)
Anatomy Link Frequency
pancreas 1
Spink3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 2 95.64 Very High Very High Very High
Chronic pancreatitis 16 93.92 High High
Inflammation 7 33.12 Quite Low
cytokine 9 30.20 Quite Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 2 95.64 Very High Very High Very High
Frailty 2 95.24 Very High Very High Very High
Adenocarcinoma 10 94.60 High High
Pancreatitis 54 93.92 High High
Death 2 90.88 High High
Targeted Disruption 41 85.36 High High
Disease 6 64.48 Quite High
INFLAMMATION 7 33.12 Quite Low
Apoptosis 8 12.24 Low Low
Edema 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor alpha (TGF alpha) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation.
Gene_expression (expression) of serine protease inhibitor Kazal type 3 associated with adenocarcinoma
1) Confidence 0.57 Published 2010 Journal Exp. Anim. Section Abstract Doc Link 20660988 Disease Relevance 0.94 Pain Relevance 0.46
Furthermore, expression of epidermal growth factor receptor (EGFR) and its ligands; serine protease inhibitor Kazal type 3 (Spink3) and transforming growth factor alpha (TGF alpha) and activation of K-Ras (GTP-Ras formation), which are frequently observed in human PDA, were indeed observed in parallel with TCs formation.
Gene_expression (expression) of Spink3 associated with adenocarcinoma
2) Confidence 0.57 Published 2010 Journal Exp. Anim. Section Abstract Doc Link 20660988 Disease Relevance 0.94 Pain Relevance 0.46
However, the authors did not find enhanced trypsin activity in the developing pancreas in the absence of SPINK3.
Neg (absence) Gene_expression (absence) of SPINK3 in pancreas
3) Confidence 0.38 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1637108 Disease Relevance 0.77 Pain Relevance 0

General Comments

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