INT16949

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.47
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CLPP) mitochondrion (CLPP)
Anatomy Link Frequency
brain 1
cleavage 1
heart 1
CLPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 11 99.50 Very High Very High Very High
substance P 9 99.00 Very High Very High Very High
cytokine 10 98.44 Very High Very High Very High
Opioid 1 98.40 Very High Very High Very High
Inflammation 9 98.12 Very High Very High Very High
Dynorphin 2 97.72 Very High Very High Very High
Enkephalin 3 94.16 High High
Somatostatin 2 92.16 High High
bradykinin 2 89.88 High High
antagonist 4 88.80 High High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 14 99.40 Very High Very High Very High
Pressure And Volume Under Development 5 98.68 Very High Very High Very High
INFLAMMATION 9 98.12 Very High Very High Very High
Disease 1 96.08 Very High Very High Very High
Natriuresis 14 94.12 High High
Asthma 1 87.12 High High
Lumbar Puncture Related Headaches 1 71.52 Quite High
Increased Venous Pressure Under Development 5 71.12 Quite High
Epilepsy 1 70.64 Quite High
Obesity 44 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, those clinical effects of the drug which have been attributed to the involvement of central opioid mechanisms may depend on the inhibition of brain converting enzyme but not the inhibition of brain neutral endopeptidase.
Negative_regulation (inhibition) of endopeptidase in brain associated with opioid
1) Confidence 0.49 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 8384953 Disease Relevance 0.14 Pain Relevance 0.10
The amino- and endopeptidase activities had pH optima at 6.5 and 7, respectively, and were both inhibited by metal ion chelators and sulphydryl group blocking agents.
Negative_regulation (inhibited) of endopeptidase
2) Confidence 0.32 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 3275739 Disease Relevance 0 Pain Relevance 0.35
The endopeptidase activity was not inhibited by the aminopeptidase inhibitors arphamenine or bestatin (IC50 = 9 nM and 0.1 microM, respectively, with Arg-AMC substrate).
Negative_regulation (inhibited) of endopeptidase
3) Confidence 0.32 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 3275739 Disease Relevance 0 Pain Relevance 0.29
A reduction in neutral endopeptidase has been seen in some animal models of airway inflammation, but this has not been shown in human disease. 6.
Negative_regulation (reduction) of endopeptidase associated with inflammation and disease
4) Confidence 0.28 Published 1997 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 9131297 Disease Relevance 0.66 Pain Relevance 0.56
Detection of endopeptidase activity and analysis of cleavage specificity using a radiometric solid-phase enzymatic assay.
Negative_regulation (Detection) of endopeptidase in cleavage
5) Confidence 0.20 Published 1991 Journal Anal. Biochem. Section Title Doc Link 1862941 Disease Relevance 0 Pain Relevance 0.08
The intensity and duration of the inhibitory effect of h alpha CGRP were potentiated by the inhibitor of neutral endopeptidase, thiorphan, while captopril and bestatin were without effect.
Negative_regulation (inhibitor) of endopeptidase associated with calcitonin gene-related peptide
6) Confidence 0.09 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 7524118 Disease Relevance 0 Pain Relevance 0.54
For example, neutral endopeptidase inhibitors are in clinical development for the treatment of arterial hypertension and heart failure (40).
Negative_regulation (inhibitors) of endopeptidase in heart associated with heart rate under development and pressure and volume under development
7) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.60 Pain Relevance 0
Neutral endopeptidase inhibition may promote lipid mobilization and oxidation.
Negative_regulation (inhibition) of endopeptidase
8) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.75 Pain Relevance 0
Addition of thiorphan (100 nM), an inhibitor of neutral endopeptidase, enhanced the levels of SP-stimulated cytokine release.
Negative_regulation (inhibitor) of endopeptidase associated with cytokine and substance p
9) Confidence 0.04 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657523 Disease Relevance 0.32 Pain Relevance 0.91

General Comments

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