INT169491

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.22
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mirlet7a-1)
Anatomy Link Frequency
HeLa 2
brain 2
lung 2
Mirlet7a-1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 69 99.70 Very High Very High Very High
tolerance 5 98.96 Very High Very High Very High
Opioid 5 98.96 Very High Very High Very High
Antinociceptive 1 98.68 Very High Very High Very High
Morphine 2 94.92 High High
Osteoarthritis 25 92.80 High High
mu opioid receptor 7 90.60 High High
Inflammation 34 50.00 Quite Low
agonist 27 5.00 Very Low Very Low Very Low
cINOD 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 853 100.00 Very High Very High Very High
Rheumatoid Arthritis 75 99.70 Very High Very High Very High
Lung Cancer 33 99.40 Very High Very High Very High
Repression 13 98.84 Very High Very High Very High
Adenocarcinoma 30 93.32 High High
Heart Rate Under Development 6 93.12 High High
Osteoarthritis 24 92.80 High High
Chronic Lymphoid Leukemia 42 91.12 High High
Apoptosis 196 90.76 High High
Colon Cancer 64 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LNA-let-7 inhibitor decreased brain let-7 levels and partially attenuated opioid antinociceptive tolerance in mice.
Negative_regulation (decreased) of Gene_expression (levels) of let-7 in brain associated with tolerance, antinociceptive and opioid
1) Confidence 0.37 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 1.16
Early research findings showed reduced let-7 expression in cancer and further studies suggested the role and biological significance of let-7 in prognosis.
Negative_regulation (reduced) of Gene_expression (expression) of let-7 associated with cancer
2) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.00 Pain Relevance 0
Takamizawa et al. analyzed 20 human lung cancer cell lines as well as 16 primary human lung cancer tissues and noticed that the reduction in let-7 expression was a frequent occurrence when compared to controls [65].
Negative_regulation (reduction) of Gene_expression (expression) of let-7 in lung associated with lung cancer
3) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.86 Pain Relevance 0
Similar to the other highly studied miRNAs, many miRNA expression studies have revealed reduced expression of the let-7 family in various types of cancer.
Negative_regulation (reduced) of Gene_expression (expression) of let-7 associated with cancer
4) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.72 Pain Relevance 0
Unsupervised hierarchical analysis classified the specimens into two groups, displaying significantly shorter post-operative survival in cases with reduced let-7 expression.
Negative_regulation (reduced) of Gene_expression (expression) of let-7
5) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.76 Pain Relevance 0
RA patient PBMCs exhibit increased expression of Let-7a, miR-26a, 146a,b, 150, and 155
Negative_regulation (exhibit) of Gene_expression (expression) of Let-7a associated with rheumatoid arthritis
6) Confidence 0.04 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.75 Pain Relevance 0.37
Upon treatment of Colo-357 with G2535, the oncogenic miRNAs miR-17, miR-19b-1, miR-20a, miR-106a, miR-200b and miR-221 showed decreased expression and the tumor suppressor miRNAs let-7a, let-7b, let-7c, let-7d, let-7f, let-7i and miR-16-1 showed increased expression.
Negative_regulation (decreased) of Gene_expression (expression) of let-7a associated with cancer
7) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.37 Pain Relevance 0
In contrast, transfection of HeLa cells with anti-sense let-7 molecules reduced the expression of let-7 and in turn, allowed for an approximately 70% increase in RAS levels [66].
Negative_regulation (reduced) of Gene_expression (expression) of let-7 in HeLa
8) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.61 Pain Relevance 0
represses the expression of the let-7C miRNA, which in turn releases the repression of c-myc expression [Shah et al., 2007].
Negative_regulation (represses) of Gene_expression (expression) of let-7C miRNA associated with repression
9) Confidence 0.01 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.31 Pain Relevance 0
to suppress let-7C gene expression

[74].

Negative_regulation (suppress) of Gene_expression (expression) of let-7C gene
10) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.45 Pain Relevance 0
However, let-7C expression was not decreased and the
Neg (not) Negative_regulation (decreased) of Gene_expression (expression) of let-7C
11) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.39 Pain Relevance 0

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