INT169492

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 36
Disease Relevance 14.85
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mirlet7a-1)
Anatomy Link Frequency
lung 4
HeLa 2
SH-SY5Y 1
liver 1
brain 1
Mirlet7a-1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 22 99.92 Very High Very High Very High
mu opioid receptor 21 99.80 Very High Very High Very High
Opioid 15 99.72 Very High Very High Very High
rheumatoid arthritis 277 99.64 Very High Very High Very High
Osteoarthritis 100 99.48 Very High Very High Very High
Morphine 6 99.46 Very High Very High Very High
Antinociceptive 3 98.68 Very High Very High Very High
Inflammatory response 21 74.16 Quite High
Inflammation 138 65.36 Quite High
cytokine 79 44.80 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1907 100.00 Very High Very High Very High
Death 61 99.68 Very High Very High Very High
Rheumatoid Arthritis 286 99.64 Very High Very High Very High
Osteoarthritis 96 99.48 Very High Very High Very High
Lung Cancer 77 99.14 Very High Very High Very High
Liver Cancer 39 98.84 Very High Very High Very High
Repression 25 98.84 Very High Very High Very High
Disease 167 98.52 Very High Very High Very High
Cryptosporidiosis 1 97.92 Very High Very High Very High
Infection 12 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, morphine significantly upregulated let-7 expression in SH-SY5Y cells and in a mouse model of opioid tolerance.
Gene_expression (expression) of let-7 in SH-SY5Y associated with tolerance, opioid and morphine
1) Confidence 0.67 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 1.13
Regulation of opioid tolerance by let-7 family microRNA targeting the mu opioid receptor.
Gene_expression (targeting) of let-7 associated with mu opioid receptor, tolerance and opioid
2) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Title Doc Link 20668208 Disease Relevance 0 Pain Relevance 1.07
The LNA-let-7 inhibitor decreased brain let-7 levels and partially attenuated opioid antinociceptive tolerance in mice.
Gene_expression (levels) of let-7 in brain associated with tolerance, antinociceptive and opioid
3) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 1.16
In our SAGE-Illumina sequencing data, both Smad7 and Tmem55a were up-regulated under activation, which was opposite to the expression of let-7a-5C (Fig. 3A).
Gene_expression (expression) of let-7a-5C
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
For the physiological significance, let-7a-5C is highly expressed during delayed implantation compared to activation group.
Gene_expression (expressed) of let-7a-5C
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0.09 Pain Relevance 0
-UTR segment of each mouse gene predicted as target genes of let-7a-5C (C at the 5th position of let-7a) or let-7a (the reference sequence of let-7a, G at the 5th position) was amplified by PCR from mouse cDNAs and inserted into the downstream of luciferase reporter gene in the pGL3 control vector.
Gene_expression (position) of let-7a
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Compared to let-7a precursor, both Timp3 and Smad7 were significantly inhibited by let-7a-5C precursor (Fig. 2C).
Gene_expression (precursor) of let-7a-5C
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Klf9, Gatm and Dnajb9 were predicted to be the target genes of unedited let-7a, whereas Tmem55a, Timp3 and Smad7 were predicted to be target genes of edited let-7a-5C.
Gene_expression (predicted) of let-7a
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
-UTR segment of each mouse gene predicted as target genes of let-7a-5C (C at the 5th position of let-7a) or let-7a (the reference sequence of let-7a, G at the 5th position) was amplified by PCR from mouse cDNAs and inserted into the downstream of luciferase reporter gene in the pGL3 control vector.
Gene_expression (position) of let-7a
9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
-UTR segment of each mouse gene predicted as target genes of let-7a-5C (C at the 5th position of let-7a) or let-7a (the reference sequence of let-7a, G at the 5th position) was amplified by PCR from mouse cDNAs and inserted into the downstream of luciferase reporter gene in the pGL3 control vector.
Gene_expression (position) of let-7a-5C
10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Klf9, Gatm and Dnajb9 were predicted to be the target genes of unedited let-7a, whereas Tmem55a, Timp3 and Smad7 were predicted to be target genes of edited let-7a-5C.
Gene_expression (predicted) of let-7a-5C
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Compared to let-7a precursor, both Timp3 and Smad7 were significantly inhibited by let-7a-5C precursor (Fig. 2C).
Gene_expression (precursor) of let-7a
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
For let-7a, the editing rate at position 5 under delayed implantation was significantly higher than that under activation (Fig. 1C).
Gene_expression (higher) of let-7a
13) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
Upon treatment of Colo-357 with G2535, the oncogenic miRNAs miR-17, miR-19b-1, miR-20a, miR-106a, miR-200b and miR-221 showed decreased expression and the tumor suppressor miRNAs let-7a, let-7b, let-7c, let-7d, let-7f, let-7i and miR-16-1 showed increased expression.
Gene_expression (expression) of let-7a associated with cancer
14) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.37 Pain Relevance 0
There was no significant difference in the expression level of Let-7a between RA, OA patients and healthy subjects (Figure 2A).
Gene_expression (expression) of Let-7a associated with rheumatoid arthritis and osteoarthritis
15) Confidence 0.07 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.37 Pain Relevance 0.62
RA patient PBMCs exhibit increased expression of Let-7a, miR-26a, 146a,b, 150, and 155
Gene_expression (expression) of Let-7a associated with rheumatoid arthritis
16) Confidence 0.07 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.75 Pain Relevance 0.37
For example, the expression of let-7 has been shown to be lower in lung cancer tissue than in normal lung tissue, and such down-regulation may promote high levels of expression of the Ras gene [30].
Gene_expression (expression) of let-7 in lung associated with lung cancer
17) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.19 Pain Relevance 0.31
The expression of let-7a, miR-26a, 146a,b, 150, and 155 between expanded IL-17 producing T cells and non-expanded cells was compared by using real-time PCR to confirm the results of microarray analysis.
Gene_expression (expression) of let-7a in T cells
18) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0 Pain Relevance 0
They found that over-expressing let-7 consistently reduced the number of proliferating cells in both cell lines [81].
Gene_expression (expressing) of let-7
19) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.79 Pain Relevance 0
Takamizawa et al. analyzed 20 human lung cancer cell lines as well as 16 primary human lung cancer tissues and noticed that the reduction in let-7 expression was a frequent occurrence when compared to controls [65].
Gene_expression (expression) of let-7 in lung associated with lung cancer
20) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.86 Pain Relevance 0

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