INT169495

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.00
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mirlet7a-1)
Anatomy Link Frequency
SH-SY5Y 2
brain 1
epithelial cells 1
Mirlet7a-1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 22 99.76 Very High Very High Very High
mu opioid receptor 21 99.38 Very High Very High Very High
Opioid 15 99.36 Very High Very High Very High
Morphine 6 97.52 Very High Very High Very High
Antinociceptive 3 97.52 Very High Very High Very High
Inflammation 112 90.60 High High
agonist 124 84.08 Quite High
Inflammatory response 23 73.84 Quite High
cytokine 55 44.48 Quite Low
fibrosis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 17 100.00 Very High Very High Very High
Cancer 504 99.98 Very High Very High Very High
Cryptosporidiosis 1 99.36 Very High Very High Very High
Epstein-barr Virus 1 98.92 Very High Very High Very High
Infection 13 98.44 Very High Very High Very High
Death 16 97.32 Very High Very High Very High
Lung Cancer 12 94.44 High High
INFLAMMATION 137 90.60 High High
Heart Rate Under Development 7 89.76 High High
Adenocarcinoma 10 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The repressive regulation of MOR by let-7 was revealed using a LNA-let-7 inhibitor to knockdown let-7 in SH-SY5Y cells.
Negative_regulation (inhibitor) of LNA-let-7 in SH-SY5Y associated with mu opioid receptor
1) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 1.08
The LNA-let-7 inhibitor decreased brain let-7 levels and partially attenuated opioid antinociceptive tolerance in mice.
Negative_regulation (inhibitor) of LNA-let-7 in brain associated with tolerance, antinociceptive and opioid
2) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 1.16
The repressive regulation of MOR by let-7 was revealed using a LNA-let-7 inhibitor to knockdown let-7 in SH-SY5Y cells.
Negative_regulation (knockdown) of let-7 in SH-SY5Y associated with mu opioid receptor
3) Confidence 0.37 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 1.09
Research has also determined exact targets of this tumor suppressing let-7 family.
Negative_regulation (suppressing) of let-7 associated with cancer
4) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.59 Pain Relevance 0
In contrast, decreasing the levels of the let-7 family caused radio-resistance [83].
Negative_regulation (decreasing) of let-7
5) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.50 Pain Relevance 0
Human biliary epithelial cells (cholangiocytes) express let-7 family members, which are decreased in response to Cryptosporidium parvum infection and LPS, and are associated with upregulation of TLR4 and improved epithelial defense responses [37].


Negative_regulation (decreased) of let-7 in epithelial cells associated with cryptosporidiosis and infection
6) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.50 Pain Relevance 0.07
Let-7 is downregulated in some cancers including Burkitt lymphoma [272] thereby leading to elevated IL-6 production, likely due to activation of the oncogenic NF-?
Negative_regulation (downregulated) of Let-7 associated with cancer and epstein-barr virus
7) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.96 Pain Relevance 0.13
-dependent repression of let-7C is
Negative_regulation (repression) of let-7C associated with repression
8) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.50 Pain Relevance 0
protein do not show this repression of the let-7C miRNA [Yang et al., 2008].
Negative_regulation (repression) of let-7C miRNA associated with repression
9) Confidence 0.01 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.41 Pain Relevance 0
downregulation of let-7C and induced c-myc and mir-17 expression [74].
Negative_regulation (downregulation) of let-7C
10) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.53 Pain Relevance 0

General Comments

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