INT169502

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
cytoplasm (Mirlet7a-1)
Anatomy Link Frequency
SH-SY5Y 1
Mirlet7a-1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 14 100.00 Very High Very High Very High
Opioid 10 99.56 Very High Very High Very High
tolerance 10 99.28 Very High Very High Very High
Morphine 4 92.72 High High
Antinociceptive 2 77.04 Quite High
Disease Link Frequency Relevance Heat
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The repressive regulation of MOR by let-7 was revealed using a LNA-let-7 inhibitor to knockdown let-7 in SH-SY5Y cells.
let-7 Regulation (regulation) of MOR in SH-SY5Y associated with mu opioid receptor
1) Confidence 0.53 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 0.99
This study aimed to test whether let-7 microRNAs can regulate the mu opioid receptor (MOR) and opioid tolerance.
let-7 Regulation (regulate) of mu opioid receptor associated with tolerance, mu opioid receptor and opioid
2) Confidence 0.39 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668208 Disease Relevance 0 Pain Relevance 0.82

General Comments

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