INT169503

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (MBD1) nucleus (MBD1) DNA binding (MBD1)
Anatomy Link Frequency
ganglion 1
MBD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Piles 3 50.00 Quite Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Neurolysis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 73.44 Quite High
Anorectal Disorders 3 71.92 Quite High
Ganglion Cysts 3 70.24 Quite High
Reprotox - General 3 1 68.44 Quite High
Cancer 47 66.52 Quite High
Myelodysplastic Syndromes 58 50.00 Quite Low
Genomic Instability 1 15.48 Low Low
Repression 1 15.20 Low Low
Myeloid Leukemia 46 5.00 Very Low Very Low Very Low
Vomiting 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Our data suggest that RFT destruction of ganglion impar in patients with chronic coccydynia has an effective outcome and patients responding to RFT have significantly lower post-RFT pain scores.
Gene_expression (destruction) of RFT in ganglion
1) Confidence 0.57 Published 2010 Journal Turk Neurosurg Section Body Doc Link 20669105 Disease Relevance 0.21 Pain Relevance 0
Chromatin remodeling involves proteins with high affinity for methylated CpGs, known as methyl CpG binding proteins MeCP2, MBD1, MBD4 and Kaiso, which mediate the inhibitory effect of CpG island methylation on gene expression acting as transcriptional repressors.
Gene_expression (expression) of MBD1
2) Confidence 0.30 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.31 Pain Relevance 0

General Comments

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