INT169505

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 4.23
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
uterine 3
smooth muscle cells 2
Oxtr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 136 99.80 Very High Very High Very High
antagonist 66 99.80 Very High Very High Very High
Inflammation 101 99.60 Very High Very High Very High
Dismenorea 25 98.82 Very High Very High Very High
Neuropeptide 5 98.22 Very High Very High Very High
chemokine 3 93.64 High High
Inflammatory stimuli 2 79.36 Quite High
bradykinin 25 44.16 Quite Low
Potency 4 39.92 Quite Low
corticosteroid 10 37.68 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 115 99.60 Very High Very High Very High
Dysmenorrhea 25 98.82 Very High Very High Very High
Natriuresis 12 96.96 Very High Very High Very High
Asthma 173 96.68 Very High Very High Very High
Embryonal Carcinoma 92 94.04 High High
Targeted Disruption 118 91.92 High High
Repression 4 65.44 Quite High
Obesity 5 61.52 Quite High
Cancer 26 59.20 Quite High
Premature Birth 63 58.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
or IL-13 correlated with changes in total mRNA levels (Figures 1A and 1B), suggesting that inflammatory cytokines possibly upregulate oxytocin receptor in HASMCs at the transcriptional level.


Spec (possibly) Positive_regulation (upregulate) of oxytocin receptor associated with inflammation and cytokine
1) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.20 Pain Relevance 0.27
These 3-D models of activated OTR (OTR Gq11) and human vasopressin V1aR were described previously [38].
Positive_regulation (activated) of OTR
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0
Others found that lysophospholipids increased translation of oxytocin receptor possibly as a consequence of increased mRNA stability [46].
Spec (possibly) Positive_regulation (increased) of oxytocin receptor
3) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.54 Pain Relevance 0.26
Our report is the first to demonstrate that expression of oxytocin receptor is increased in HASMCs treated with pro-inflammatory cytokines, either TNF?
Positive_regulation (increased) of oxytocin receptor associated with inflammation and cytokine
4) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.41 Pain Relevance 0.27
Oxytocin, a hypothalamic neuropeptide, induces uterine contractions during parturition and milk ejection during lactation via activation of the oxytocin receptor, a G protein-coupled receptor [1].
Positive_regulation (activation) of oxytocin receptor in uterine associated with dismenorea and neuropeptide
5) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.40 Pain Relevance 0.19
Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNF?
Positive_regulation (activation) of oxytocin receptor in smooth muscle cells
6) Confidence 0.38 Published 2010 Journal Respir Res Section Title Doc Link PMC2922094 Disease Relevance 0.48 Pain Relevance 0.16
Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13.
Positive_regulation (activation) of oxytocin receptor in smooth muscle cells
7) Confidence 0.37 Published 2010 Journal Respir. Res. Section Title Doc Link 20670427 Disease Relevance 0.36 Pain Relevance 0.17
These 3-D models of activated OTR (OTR Gq11) and human vasopressin V1aR were described previously [38].
Positive_regulation (activated) of OTR
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0
Further data suggest that an activation of OTR provide a local Ca2+ signal that induces eNOS activation [15] and possibly natriuretic peptides [11].
Positive_regulation (activation) of OTR associated with natriuresis
9) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.25 Pain Relevance 0
This was significantly reduced in cells subjected for the both siRNA treatments (OTR - Fig. 3H, respectively V1aR - Fig. 3J).
Positive_regulation (respectively) of OTR
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.18 Pain Relevance 0.11
Bilateral ovariectomy or administration of a progesterone antagonist (RU-486) induces uterine oxytocin receptor and connexin-43 and leads to pup delivery within 16–24 hours in the Cox-1, cPLA2 and PGF2?
Positive_regulation (induces) of uterine oxytocin receptor in uterine associated with antagonist
11) Confidence 0.14 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.62 Pain Relevance 0.09
which causes luteolysis and a fall in progesterone resulting in induction of uterine prostaglandin receptors, oxytocin receptor and connexin-43, leading to increased contractions and pup delivery [13].
Positive_regulation (induction) of oxytocin receptor in uterine
12) Confidence 0.13 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.23 Pain Relevance 0
B leads directly to high levels of COX-2, PGE2, the gap junction protein connexin 43, and upregulation of the oxytocin receptor [20].
Positive_regulation (upregulation) of oxytocin receptor
13) Confidence 0.07 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.55 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox