INT169538

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.41
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
brain 2
Bax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diclofenac 5 81.68 Quite High
Inflammation 13 76.52 Quite High
ischemia 39 71.84 Quite High
cva 4 68.24 Quite High
cINOD 2 53.64 Quite High
Glutamate 2 35.32 Quite Low
Neurotransmitter 2 34.92 Quite Low
Central nervous system 13 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 173 96.04 Very High Very High Very High
Death 35 92.32 High High
Disease 18 91.24 High High
Injury 10 80.80 Quite High
Hypoxia 9 80.52 Quite High
INFLAMMATION 14 76.52 Quite High
Colon Cancer 4 75.00 Quite High
Cv General 4 Under Development 12 72.56 Quite High
Stroke 36 72.32 Quite High
Carbon Monoxide Poisoning 1 38.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DMH treatment reduced the mitochondrial translocation of Bax whereas cytochrome c was found to be located prominently in the mitochondria.
Negative_regulation (reduced) of Localization (translocation) of Bax
1) Confidence 0.49 Published 2010 Journal Oncol. Res. Section Abstract Doc Link 20681407 Disease Relevance 0.40 Pain Relevance 0.27
B)- and p53-dependent pathways, decreased Bcl-2 to Bax ratio, release of cytochrome c oxidase from mitochondria and caspase activation, and eventually activate DNA-breaking enzymes and the energy-consuming DNA repair enzymes resulting in DNA breakdown and cell death.5,6 Massive cell death in the brain harms neural network and ultimately impairs neurological functions.
Negative_regulation (decreased) of Localization (release) of Bax in brain associated with death
2) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695239 Disease Relevance 0.55 Pain Relevance 0.07
Mechanistic events of how Mito-KATP exerts its protective effect has been unclear, but a recent study showed that activation of Mito-KATP by diazoxide increases the association of Bcl-2 with mitochondria, while prevents Bax translocation to mitochondria [74].


Negative_regulation (prevents) of Localization (translocation) of Bax
3) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.46 Pain Relevance 0

General Comments

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