INT169552

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
prefrontal 3
nucleus accumbens 1
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 53 100.00 Very High Very High Very High
Nucleus accumbens 7 100.00 Very High Very High Very High
Ventral tegmentum 2 100.00 Very High Very High Very High
cocaine 111 99.98 Very High Very High Very High
opioid receptor 6 95.44 Very High Very High Very High
Opioid 8 86.48 High High
Eae 21 25.56 Quite Low
fluoxetine 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 91.88 High High
Obesity 6 70.96 Quite High
Sprains And Strains 4 28.96 Quite Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these DAT-CI mice, cocaine suppresses locomotion and does not produce reward, supporting the hypothesis that cocaine blockade of DAT is required for cocaine reward in normal mice [17].
Positive_regulation (required) of Negative_regulation (blockade) of DAT associated with cocaine
1) Confidence 0.50 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.09 Pain Relevance 0.69
Gene expression, measured using quantitative real-time PCR, revealed a significant approximately 3- to 10-fold up-regulation of dopamine reuptake transporter (DAT) in the ventral tegmental area, nucleus accumbens, and prefrontal cortex and a down-regulation of DAT in the hypothalamus.
Positive_regulation (up-regulation) of Negative_regulation (down-regulation) of DAT in prefrontal associated with nucleus accumbens, ventral tegmentum and dopamine
2) Confidence 0.39 Published 2010 Journal Endocrinology Section Abstract Doc Link 20685869 Disease Relevance 0.21 Pain Relevance 0.68
Gene expression, measured using quantitative real-time PCR, revealed a significant approximately 3- to 10-fold up-regulation of dopamine reuptake transporter (DAT) in the ventral tegmental area, nucleus accumbens, and prefrontal cortex and a down-regulation of DAT in the hypothalamus.
Positive_regulation (up-regulation) of in nucleus accumbens Negative_regulation (down-regulation) of DAT in prefrontal associated with nucleus accumbens, ventral tegmentum and dopamine
3) Confidence 0.13 Published 2010 Journal Endocrinology Section Abstract Doc Link 20685869 Disease Relevance 0.21 Pain Relevance 0.68

General Comments

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