INT169553

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.94
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 1
bile 1
prefrontal 1
Slc37a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 210 100.00 Very High Very High Very High
Bile 53 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
gABA 2 99.98 Very High Very High Very High
GABA receptor 1 99.60 Very High Very High Very High
Ventral tegmentum 5 99.44 Very High Very High Very High
Glutamate receptor 1 99.38 Very High Very High Very High
Nucleus accumbens 6 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 4 99.90 Very High Very High Very High
Targeted Disruption 27 98.36 Very High Very High Very High
Diabetes Mellitus 107 97.68 Very High Very High Very High
Obesity 15 95.56 Very High Very High Very High
Cardiovascular Disease 3 90.76 High High
Leukemia 1 90.36 High High
Crystal Associated Disease 13 89.64 High High
INFLAMMATION 2 89.44 High High
Metabolic Syndrome 5 89.00 High High
Disease 4 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene expression, measured using quantitative real-time PCR, revealed a significant approximately 3- to 10-fold up-regulation of dopamine reuptake transporter (DAT) in the ventral tegmental area, nucleus accumbens, and prefrontal cortex and a down-regulation of DAT in the hypothalamus.
Positive_regulation (up-regulation) of transporter in prefrontal associated with nucleus accumbens, ventral tegmentum and dopamine
1) Confidence 0.13 Published 2010 Journal Endocrinology Section Abstract Doc Link 20685869 Disease Relevance 0.21 Pain Relevance 0.66
Based on the observation that GLVR1 possesses sequence similarity to pho-4+, a phosphate (Pi) permease of Neurospora crassa, several groups have demonstrated that GLVR1 is a high affinity Na+-dependent Pi transporter, which was consequently renamed PiT1 [2], [3], [4].
Positive_regulation (dependent) of transporter
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.09 Pain Relevance 0
Among mediators of neurotransmission, multiple glutamate receptors (Gria3, Gria4, Grik1), a GABA transporter (Slc6a1), a serotonin receptor (Htr3a) and the neuropeptide somatostatin are increased, while a GABA receptor (Gabra2) and neuropeptides with specific sensory roles (Galanin, Adcyap1/PACAP) are decreased.
Positive_regulation (increased) of transporter associated with gaba, gaba receptor, glutamate receptor, somatostatin, neuropeptide and serotonin
3) Confidence 0.07 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.35 Pain Relevance 0.38
Furthermore, it should be underlined that locomotor actions of amphetamines observed in DDD mice occur at doses that are much higher than necessary to induce classic transporter-mediated effects [10,38,83].
Positive_regulation (induce) of transporter
4) Confidence 0.05 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0 Pain Relevance 0.46
Gene expression, measured using quantitative real-time PCR, revealed a significant approximately 3- to 10-fold up-regulation of dopamine reuptake transporter (DAT) in the ventral tegmental area, nucleus accumbens, and prefrontal cortex and a down-regulation of DAT in the hypothalamus.
Positive_regulation (up-regulation) of transporter in nucleus accumbens associated with nucleus accumbens, ventral tegmentum and dopamine
5) Confidence 0.04 Published 2010 Journal Endocrinology Section Abstract Doc Link 20685869 Disease Relevance 0.21 Pain Relevance 0.66
In summary, in the widely studied cftr knockout mouse model (which clearly demonstrates intestinal pathology), the apical sodium dependent ileal bile acid transporter is expressed and functions at higher levels than in wild-type animals, with intermediate levels of IBAT expression and function in heterozygous cftr (+/-) mice.
Positive_regulation (dependent) of transporter in bile associated with targeted disruption and bile
6) Confidence 0.04 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.36 Pain Relevance 0.32
In this paper we have translated the genetic association of the SLC2A9 locus with serum urate derived from genome-wide scanning into a functional confirmation that SLC2A9 splice variants acts as a high-capacity urate transporter that can be facilitated by exchange with hexoses and inhibited by high concentrations of some uricosurics and siRNA technology.
Positive_regulation (facilitated) of transporter
7) Confidence 0.01 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.63 Pain Relevance 0
Indeed, a recent paper showed that green tea supplementation for 12 weeks ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model resembling the human type 2 diabetes mellitus [3].
Positive_regulation (increases) of transporter IV associated with diabetes mellitus and insulin resistance
8) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.68 Pain Relevance 0
The amelioration of insulin resistance by green tea is associated with the increased expression level of glucose transporter IV in a fructose-fed rat [3].
Positive_regulation (increased) of transporter IV associated with insulin resistance
9) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.41 Pain Relevance 0

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