INT169555

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.55
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Acpp) plasma membrane (Acpp) intracellular (Acpp)
lysosome (Acpp)
Anatomy Link Frequency
neurons 4
nerve 1
Acpp (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 13 99.98 Very High Very High Very High
antinociception 10 99.96 Very High Very High Very High
dorsal root ganglion 4 99.36 Very High Very High Very High
adenocard 67 99.22 Very High Very High Very High
Thermal hyperalgesia 15 98.16 Very High Very High Very High
allodynia 14 96.72 Very High Very High Very High
bradykinin 4 96.32 Very High Very High Very High
Inflammation 17 93.92 High High
Antinociceptive 44 93.00 High High
Lasting pain 19 92.80 High High
Disease Link Frequency Relevance Heat
Nociception 43 99.84 Very High Very High Very High
Prostate Cancer 3 99.56 Very High Very High Very High
Ganglion Cysts 4 98.88 Very High Very High Very High
Hyperalgesia 15 98.16 Very High Very High Very High
Neuropathic Pain 19 96.72 Very High Very High Very High
Cancer 56 95.56 Very High Very High Very High
INFLAMMATION 17 93.92 High High
Nervous System Injury 10 93.36 High High
Pain 27 92.80 High High
Hypoxia 1 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons, functions as an ectonucleotidase, and generates adenosine extracellularly.
Gene_expression (expressed) of Prostatic acid phosphatase in neurons associated with ganglion cysts, nociception, dorsal root ganglion and adenocard
1) Confidence 0.68 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20685973 Disease Relevance 0.57 Pain Relevance 0.46
Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons, functions as an ectonucleotidase, and generates adenosine extracellularly.
Gene_expression (expressed) of PAP in neurons associated with ganglion cysts, nociception, dorsal root ganglion and adenocard
2) Confidence 0.68 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20685973 Disease Relevance 0.57 Pain Relevance 0.46
Conversely, PIP(2) levels were significantly elevated in DRGs from Pap(-/-) mice, and this correlated with enhanced thermal hyperalgesia and mechanical allodynia in Pap(-/-) mice.
Gene_expression (elevated) of Pap associated with allodynia and thermal hyperalgesia
3) Confidence 0.59 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20685973 Disease Relevance 1.20 Pain Relevance 0.91
In mice, intrathecal injection of PAP reduced PIP(2) levels in DRGs, inhibited thermosensation through TRPV1, and enduringly reduced thermal hyperalgesia and mechanical allodynia caused by inflammation, nerve injury, and pronociceptive receptor activation.
Gene_expression (injection) of PAP in nerve associated with nervous system injury, inflammation, allodynia, thermal hyperalgesia and intrathecal
4) Confidence 0.51 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20685973 Disease Relevance 0.89 Pain Relevance 0.75
In addition, we observed that NT5E was extensively co-localized with Prostatic acid phosphatase (PAP, also known as ACPP, Fluoride-resistant acid phosphatase or thiamine monophosphatase) in nociceptive neurons.
Gene_expression (with) of Prostatic acid phosphatase in neurons associated with nociception
5) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 1.18 Pain Relevance 0.76
Recombinant Mouse PAP Has pH-Dependent Ectonucleotidase Activity and Acts through A1-Adenosine Receptors to Mediate Antinociception

Prostatic acid phosphatase (PAP) is expressed in nociceptive neurons and functions as an ectonucleotidase.

Gene_expression (expressed) of Prostatic acid phosphatase in neurons associated with nociception, antinociception and adenocard
6) Confidence 0.15 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2617779 Disease Relevance 0.16 Pain Relevance 0.62
Previously, we found that TMPase was molecularly identical to Prostatic acid phosphatase (PAP) using mice.
Gene_expression (using) of Prostatic acid phosphatase
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800773 Disease Relevance 0.25 Pain Relevance 0.04
While this immunotherapeutic agent is relatively inconvenient as a personalized vaccine, it seems that selecting the recombinant version of the prostatic acid phosphatase (PAPexpressed in 95% of prostatic tumor cells—as antigen was critical [2], reaffirming target selection as a key feature in cancer vaccine design.
Gene_expression (expressed) of PAP associated with cancer and prostate cancer
8) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 0.73 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox