INT169558

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 13.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (NF1) signal transduction (NF1) nucleus (NF1)
intracellular (NF1) extracellular matrix organization (NF1) cytoplasm (NF1)
Anatomy Link Frequency
coronary artery 3
blood 2
endothelial cells 1
lumen 1
lobe 1
NF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 4 50.00 Quite Low
palliative 2 49.56 Quite Low
anesthesia 6 45.76 Quite Low
imagery 22 28.96 Quite Low
Angina 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 986 100.00 Very High Very High Very High
Watson Syndrome 28 100.00 Very High Very High Very High
Cancer 44 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 24 99.40 Very High Very High Very High
Pathologic Constriction 40 98.68 Very High Very High Very High
Atherosclerosis 51 98.40 Very High Very High Very High
Nerve Sheath Neoplasms 50 96.24 Very High Very High Very High
Hyperplasia 50 91.36 High High
Cv General 2 Under Development 4 89.12 High High
Metastasis 28 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased WSS values during vasodilatation indicate that the artery is incapable to fully counteract the increase in shear stress by lumen enlargement.
Positive_regulation (increased) of WSS in lumen associated with stress and increased venous pressure under development
1) Confidence 0.59 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.88 Pain Relevance 0
It allows for an increase in mean WSS during exercise without reaching high levels that could be damaging to endothelial cells.
Positive_regulation (increase) of WSS in endothelial cells associated with stress
2) Confidence 0.59 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.95 Pain Relevance 0
During strenuous exercise the increase in mean WSS will even be more pronounced.
Positive_regulation (increase) of WSS associated with stress
3) Confidence 0.59 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.98 Pain Relevance 0
Biallelic inactivation of NF1 and mutations of numerous additional tumor suppressor genes within the p19ARF-MDM2-TP53 and p16INK4A-Rb signaling cascades have been identified in MPNSTs [12,13].
Positive_regulation (inactivation) of NF1 associated with cancer and watson syndrome
4) Confidence 0.50 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 1.85 Pain Relevance 0
Most NF1 patients carry a constitutional mutation of the NF1 tumor suppressor gene [11].
Positive_regulation (mutation) of NF1 associated with cancer and watson syndrome
5) Confidence 0.50 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 1.84 Pain Relevance 0
During exercise, after all, the arteries may have to accommodate ten times higher blood flows, which would lead to too high WSS levels when starting at a high level already, because arteries can dilate maximally 20%.
Positive_regulation (lead) of WSS in blood associated with stress
6) Confidence 0.43 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.92 Pain Relevance 0
Based upon these observations it may be concluded that at rest, mean WSS is regulated locally and depends on the characteristics of the peripheral circulation.
Positive_regulation (depends) of WSS associated with stress
7) Confidence 0.43 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.81 Pain Relevance 0
In large arteries whole blood viscosity (WBV), which can be determined by using the approximation proposed by Weaver et al. [62], is used to calculate WSS: 2where ?
Positive_regulation (calculate) of WSS in blood associated with stress
8) Confidence 0.43 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.21 Pain Relevance 0
RESULTS: Linear correlation between increase in both WSS Lac/Cr value in left temporal lobe and WSS ml/Cr value in right frontal lobe and a number of migraine attacks per year in migraine patients was observed.
Positive_regulation (increase) of WSS in lobe
9) Confidence 0.39 Published 2010 Journal Prz. Lek. Section Body Doc Link 20687355 Disease Relevance 0.09 Pain Relevance 0
Such flow features correspond typically to low time averaged WSS, long residence times, shear oscillation and increased spatial WSS gradients.
Positive_regulation (increased) of WSS associated with stress
10) Confidence 0.12 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 0.76 Pain Relevance 0
The elevated WSS in the distal coronary artery was mainly caused by increased bypass mass flow during systole.
Positive_regulation (elevated) of WSS in coronary artery associated with stress
11) Confidence 0.12 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.10 Pain Relevance 0
Across both types of anastomoses, elevated WSS values did coincide with vessel stenosis, being either caused by atherosclerotic wall changes or by a surgical clip.
Positive_regulation (elevated) of WSS associated with stress, pathologic constriction and atherosclerosis
12) Confidence 0.12 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.09 Pain Relevance 0
The elevated WSS in the distal coronary artery was mainly caused by increased bypass mass flow during systole.
Positive_regulation (caused) of WSS in coronary artery associated with stress
13) Confidence 0.08 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.12 Pain Relevance 0
There were some areas of elevated WSS close to the anastomosis, but the highest WSS values were found in the atherosclerotic distal coronary artery (Figure 8).
Positive_regulation (elevated) of WSS in coronary artery associated with stress and atherosclerosis
14) Confidence 0.08 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 0.99 Pain Relevance 0

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