INT169561

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.92
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 1
proximal 1
body 1
Dss1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 36 100.00 Very High Very High Very High
Kinase C 2 98.64 Very High Very High Very High
cINOD 1 91.48 High High
Inflammation 114 88.20 High High
cytokine 66 78.68 Quite High
Crohn's disease 16 77.76 Quite High
Inflammatory response 6 50.32 Quite High
Inflammatory mediators 15 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Cancer 25 99.84 Very High Very High Very High
Body Weight 25 99.70 Very High Very High Very High
Urological Neuroanatomy 36 99.12 Very High Very High Very High
Colitis 136 98.96 Very High Very High Very High
Colon Cancer 10 97.96 Very High Very High Very High
Weight Loss 17 94.72 High High
Disease 29 93.20 High High
INFLAMMATION 124 91.24 High High
Inflammatory Bowel Disease 98 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DSS can thus both decrease the mucus thickness and increase the permeability of the mucus to allow particles large as bacteria to quickly penetrate the inner firmly adherent mucus of colon explants.


Negative_regulation (decrease) of DSS in colon
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.16 Pain Relevance 0.08
In an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model, there was a dose-dependent decrease in tumor incidence with SK inhibitor treatment.
Negative_regulation (decrease) of DSS associated with cancer
2) Confidence 0.16 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20688834 Disease Relevance 1.26 Pain Relevance 0.21
After DSS was replaced with drinking water, MPO levels remained significantly higher at 9-day group (6-times increase as that in 5-day group).
Negative_regulation (replaced) of DSS associated with urological neuroanatomy
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.96 Pain Relevance 0.16
As shown in Fig. 1, 3-, and 5-day groups, body weight significantly decreased during the DSS-treatment, much lower than those in normal drinking water-treated mice.
Negative_regulation (decreased) of DSS in body associated with body weight
4) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.91 Pain Relevance 0.23
The reduction could be recovered after withdrawal of DSS, such as day 9 and day 14 groups.
Negative_regulation (withdrawal) of DSS associated with withdrawal
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.83 Pain Relevance 0.24
It is feasible that the reduction of DSS-mediated downregulation of ZO-1 expression by EcN treatment is one reason for the enhanced barrier stability.
Negative_regulation (reduction) of DSS
6) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.58 Pain Relevance 0.04
However, an alternative explanation is that ASF/SF2 requires the U2AF65 consensus sequence adjacent to exon 8a to be present in order for it to bind to consensus sequences downstream and repress distal splice site selection, and hence when mutated or deleted DSS repression is lifted resulting in preferential proximal splice site selection.
Negative_regulation (repression) of DSS in proximal associated with repression
7) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.15 Pain Relevance 0
This down-regulation of DSS and increased PSS was blocked by protein kinase C inhibition and SRPK1/2 inhibition.
Negative_regulation (regulation) of DSS associated with kinase c
8) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0.07 Pain Relevance 0.05

General Comments

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