INT169570

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.07
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ROS1, TRPV1) cytosol (TRPV1) cell differentiation (ROS1)
cell proliferation (ROS1) transport (TRPV1) lipid metabolic process (TRPV1)
Anatomy Link Frequency
knee joint 2
joints 1
ROS1 (Homo sapiens)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 42 99.76 Very High Very High Very High
Inflammation 164 98.08 Very High Very High Very High
Spinal cord 84 96.64 Very High Very High Very High
Inflammatory mediators 12 95.64 Very High Very High Very High
imagery 58 94.56 High High
Lasting pain 4 89.88 High High
central sensitization 20 88.80 High High
TRP channel 4 86.28 High High
antagonist 44 76.48 Quite High
agonist 32 75.92 Quite High
Disease Link Frequency Relevance Heat
Arthritis 90 99.76 Very High Very High Very High
Nociception 62 98.72 Very High Very High Very High
INFLAMMATION 136 98.08 Very High Very High Very High
Pain 28 89.88 High High
Neurogenic Inflammation 8 89.44 High High
Arthropathy 12 86.56 High High
Fever 8 76.60 Quite High
Pressure And Volume Under Development 4 74.32 Quite High
Neuropathic Pain 16 65.68 Quite High
Hyperalgesia 24 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings and those of others reported in the literature indicate reciprocal interactions between TRPV1 and ROS play critical roles in the pathological and nociceptive responses active during arthritic inflammation.


ROS Binding (interactions) of TRPV1
1) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link 20691059 Disease Relevance 0 Pain Relevance 0
In the present study, the kaolin/carrageenan (k/c) induced knee joint arthritis model in rats, as well as primary and clonal human synoviocyte cultures were used to understand the reciprocal interactions between reactive nitroxidative species (ROS) and functional TRPV1 channels.
ROS Binding (interactions) of TRPV1 in knee joint associated with arthritis
2) Confidence 0.29 Published 2010 Journal Mol Pain Section Abstract Doc Link 20691059 Disease Relevance 0.17 Pain Relevance 0.10
These findings and those of others reported in the literature indicate reciprocal interactions between TRPV1 and ROS play critical roles in the pathological and nociceptive responses active during arthritic inflammation.



ROS Binding (interactions) of TRPV1 associated with nociception, inflammation and arthritis
3) Confidence 0.23 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2924298 Disease Relevance 0.80 Pain Relevance 0.44
The current study was initiated to gain a better appreciation of reciprocal interactions between TRPV1 channels and ROS generation that contribute to neurogenic/neuroimmune inflammation and nociceptive responses.


ROS Binding (interactions) of TRPV1 associated with nociception and inflammation
4) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.72 Pain Relevance 0.35
To examine ROS and TRPV1 interactions, two arthritis models were used in the present study including (a) in vivo inflammation of the knee joint in rats induced by injecting 3% kaolin and 3% carrageenan (k/c) directly into the knee joint injection and (b) in vitro human clonal type B synoviocytes (SW982) and primary synoviocytes harvested from clinic patients with active arthropathies [19].
ROS Binding (interactions) of TRPV1 in knee joint associated with inflammation, arthropathy and arthritis
5) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.80 Pain Relevance 0.37
To further address and support this concept in the context of the local peripheral microenvironment in inflamed joints, further studies with in vitro synoviocyte models were done that provided evidence of reciprocal interactions between TRPV1 activation and ROS generation.


ROS Binding (interactions) of TRPV1 in joints
6) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.58 Pain Relevance 0.62

General Comments

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