INT169582

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.98
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (POLG) cell death (POLG) aging (POLG)
DNA binding (POLG) nucleotidyltransferase activity (POLG) DNA metabolic process (POLG)
Anatomy Link Frequency
liver 1
POLG (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 90.72 High High
Migraine 1 90.12 High High
fibrosis 32 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 1 98.66 Very High Very High Very High
Epilepsy 3 98.36 Very High Very High Very High
Neuropathic Pain 2 98.28 Very High Very High Very High
Muscle Disease 1 98.04 Very High Very High Very High
Lactic Acidosis 2 97.84 Very High Very High Very High
Toxicity 14 97.42 Very High Very High Very High
Cognitive Disorder 1 95.56 Very High Very High Very High
Acute Liver Failure 1 95.04 Very High Very High Very High
Ataxia 2 91.80 High High
Headache 2 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The form of MIRAS, starting as acute, treatment resistant epilepsy, is important to diagnose, since valproate therapy almost always leads to acute liver failure requiring liver transplantation.
Phosphorylation (form) of MIRAS in liver associated with epilepsy and acute liver failure
1) Confidence 0.54 Published 2010 Journal Duodecim Section Abstract Doc Link 20695297 Disease Relevance 1.15 Pain Relevance 0.18
The interaction can produce mitochondrial toxicity with lactic acidosis, myopathy, neuropathy and cardiomyopathy, all of which are presumably secondary to RBV-dependent increased phosphorylation of didanosine and mitochondrial DNA polymerase (polymerase-?)
Phosphorylation (phosphorylation) of mitochondrial DNA polymerase associated with toxicity, lactic acidosis, neuropathic pain, muscle disease and coronary heart disease
2) Confidence 0.04 Published 2007 Journal Journal of Viral Hepatitis Section Body Doc Link PMC1974798 Disease Relevance 0.83 Pain Relevance 0

General Comments

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