INT16959

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.77
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
groove 2
T cells 2
PBMC 2
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 81 100.00 Very High Very High Very High
Chronic low back pain 1 93.08 High High
Arthritis 19 91.36 High High
spondylitis 6 91.28 High High
backache 1 83.12 Quite High
rheumatoid arthritis 6 76.04 Quite High
Inflammation 9 44.88 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 93 100.00 Very High Very High Very High
Low Back Pain 86 100.00 Very High Very High Very High
Myelodysplastic Syndromes 8 100.00 Very High Very High Very High
Seronegative Spondarthritis 13 94.28 High High
Arthritis 12 91.36 High High
Sacroiliitis 4 89.04 High High
Sprains And Strains 1 79.92 Quite High
Targeted Disruption 8 76.64 Quite High
Rheumatoid Arthritis 7 76.04 Quite High
Spondylarthropathies 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ankylosing spondylitis in a patient with myelodysplastic syndrome: an association with HLA-B27 or coincidence?
Positive_regulation (spondylitis) of HLA-B27 Binding (association) of associated with spinal inflammation and myelodysplastic syndromes
1) Confidence 0.50 Published 2009 Journal Rheumatol. Int. Section Title Doc Link 18841370 Disease Relevance 1.46 Pain Relevance 0.68
Two of those early studies [16,17] reported an increased risk of AD associated with HLA-B7.
Positive_regulation (increased) of HLA-B7 Binding (associated) of associated with disease
2) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 0.86 Pain Relevance 0
The experimental studies reviewed here have greatly increased our knowledge of the structure, function and disease association of HLA-B27.
Positive_regulation (increased) of HLA-B27 Binding (association) of associated with disease
3) Confidence 0.48 Published 1998 Journal Mol Med Today Section Abstract Doc Link 9866824 Disease Relevance 0.79 Pain Relevance 0.38
However, the mechanism mediating the interaction between the HLA-B27 positive cell and the bacterial antigen is at present unknown.
Positive_regulation (mediating) of HLA-B27 Binding (interaction) of
4) Confidence 0.47 Published 1983 Journal Br. J. Rheumatol. Section Abstract Doc Link 6606476 Disease Relevance 0.17 Pain Relevance 0.09
Similarly, using an enzyme-linked immunosorbent assay, we detected no significant increase in antibody binding to peripheral blood mononuclear cells (PBMC) in HLA-B27 positive patients with AS.
Neg (no) Positive_regulation (increase) of HLA-B27 Binding (binding) of in PBMC associated with spinal inflammation
5) Confidence 0.45 Published 1987 Journal Arthritis Rheum. Section Abstract Doc Link 3551965 Disease Relevance 0.52 Pain Relevance 0.50
The weak association of wildtype HLA-B*2705 with the transporter associated with antigen processing could also be enhanced by mutation of residues at position 114 and 116 in the peptide-binding groove to those present in the HLA-B*2706 allele.


Positive_regulation (enhanced) of HLA-B Binding (association) of in groove
6) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575614 Disease Relevance 0.06 Pain Relevance 0.06
NK receptor mediated recognition of HLA-B27 may be responsible for peptide independent activation of these CD4+ T cells in AS disease.
Positive_regulation (mediated) of HLA-B27 Binding (recognition) of in T cells associated with spinal inflammation and disease
7) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.58 Pain Relevance 0.78
An increase of the HLA-B27/Cw1 association and the spondarthritic form was also found.
Positive_regulation (increase) of HLA-B27 Binding (association) of
8) Confidence 0.04 Published 1991 Journal Br. J. Rheumatol. Section Abstract Doc Link 1863819 Disease Relevance 1.34 Pain Relevance 0.47

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