INT169591

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 10.73
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (FAT1) plasma membrane (FAT1) nucleus (FAT1)
cell-cell signaling (FAT1) cytoplasm (FAT1)
Anatomy Link Frequency
fat 13
muscle 4
body 3
plasma 1
globules 1
FAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 100.00 Very High Very High Very High
cva 12 98.52 Very High Very High Very High
tolerance 76 93.60 High High
Inflammatory response 24 90.36 High High
Inflammation 111 88.16 High High
Restless leg syndrome 9 62.60 Quite High
analgesia 1 56.72 Quite High
iatrogenic 10 43.92 Quite Low
Catecholamine 126 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 221 99.44 Very High Very High Very High
Diabetes Mellitus 219 99.26 Very High Very High Very High
Syndrome 13 98.80 Very High Very High Very High
Fat Embolism 7 98.52 Very High Very High Very High
Insulin Resistance 92 97.32 Very High Very High Very High
Facioscapulohumeral Muscular Dystrophy 375 96.36 Very High Very High Very High
Death 18 95.36 Very High Very High Very High
Metabolic Syndrome 17 94.56 High High
Impaired Glucose Tolerance 102 93.60 High High
Overweight 121 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.75–0.9 Mb distal to FAT1, the nearest gene known to be expressed in the muscle (Figure 2).
Gene_expression (expressed) of FAT1 in muscle
1) Confidence 0.67 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.26 Pain Relevance 0
The cell type-specific differences in chromatin that we observed are consistent with tissue-specific production of multiple FAT1 RNA and protein isoforms from predicted gene-internal promoters and by alternative splicing (http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/).
Gene_expression (production) of FAT1 in internal
2) Confidence 0.67 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.53 Pain Relevance 0
Multiple DH sites in FAT1 introns were consistently seen in the myoblasts cultures (Supplementary Figure S3).
Gene_expression (sites) of FAT1 in myoblasts
3) Confidence 0.58 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.16 Pain Relevance 0
FAT1 is the only annotated 4q35.2 gene with evidence for complex tissue-specific expression and, in this study, a muscle-specific pattern of DH sites.
Gene_expression (expression) of FAT1 in muscle
4) Confidence 0.58 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.51 Pain Relevance 0
(B) DH sites in the FAT1 and MTNR1A regions are cell type-specific.
Gene_expression (sites) of FAT1
5) Confidence 0.58 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.72 Pain Relevance 0
The postmortem diagnosis of fat embolism syndrome (FES), traditionally based on the histological demonstration of fat globules seems not to be enough, nowadays.
Gene_expression (globules) of fat in globules associated with syndrome, cva and fat embolism
6) Confidence 0.42 Published 2010 Journal Coll Antropol Section Abstract Doc Link 20698162 Disease Relevance 1.14 Pain Relevance 0.19
The authors concluded that the lower carbohydrate delivery and a small difference in plasma insulin may have resulted in a higher endogenous carbohydrate use and higher fat oxidation during the isomaltulose trial than during the sucrose trial.
Gene_expression (oxidation) of fat in plasma
7) Confidence 0.14 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0.08 Pain Relevance 0
Statistically significant differences between the SOmaxP and CP cohorts were observed for 1 RM (p = 0.019), RTF (p = 0.004), body fat percent (p = 0.028), lean mass (p = 0.049), and fat mass (p = 0.023).
Gene_expression (mass) of fat in body
8) Confidence 0.14 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0 Pain Relevance 0
Statistically significant differences between the SOmaxP and CP cohorts were observed for 1 RM (p = 0.019), RTF (p = 0.004), body fat percent (p = 0.028), lean mass (p = 0.049), and fat mass (p = 0.023).
Gene_expression (percent) of fat in body
9) Confidence 0.14 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3016253 Disease Relevance 0 Pain Relevance 0
We found that muscle and fat were chief extracranial expressors, which is consistent with the literature [19].
Gene_expression (muscle) of fat in fat
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.21 Pain Relevance 0
We found that muscle and fat were chief extracranial expressors, which is consistent with the literature [19].
Gene_expression (expressors) of fat in fat
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.22 Pain Relevance 0
Given the expression of S100B in adipocytes, we investigated the relationship between fat content and S100B levels.
Gene_expression (content) of fat in adipocytes associated with obesity
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.51 Pain Relevance 0
Thus, it is feasible that HIIE fat loss programs are effective for producing a clinical decrease in fat (greater than 6% of fat mass) for some but not all participants.
Gene_expression (producing) of fat in fat
13) Confidence 0.08 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.11 Pain Relevance 0.03
As women in these studies possessed relatively low abdominal fat levels, it is possible that the greater abdominal fat of men may demonstrate greater reductions after HIIE.
Gene_expression (levels) of fat in fat
14) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.21 Pain Relevance 0
Thus, it is feasible that HIIE fat loss programs are effective for producing a clinical decrease in fat (greater than 6% of fat mass) for some but not all participants.
Gene_expression (mass) of fat in fat
15) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.16 Pain Relevance 0.03
With regard to abdominal fat, Trapp et al. [5] found that 15 weeks of HIIE led to significantly reduced abdominal fat (.15?
Gene_expression (led) of fat in fat
16) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.15 Pain Relevance 0
Possible mechanisms underlying HIIE-induced fat loss and implications for the use of HIIE in the treatment and prevention of obesity are also discussed.


1.

Spec (implications) Gene_expression (loss) of fat in fat associated with obesity
17) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Abstract Doc Link PMC2991639 Disease Relevance 0.38 Pain Relevance 0.05
With regard to abdominal fat, Trapp et al. [5] found that 15 weeks of HIIE led to significantly reduced abdominal fat (.15?
Gene_expression (found) of fat in fat
18) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.15 Pain Relevance 0
The amount of subcutaneous fat lost was similar to that observed in the Trapp et al. [5] study suggesting that shorter HIIE interventions (12 versus 15 weeks) are also effective for reducing subcutaneous fat.
Gene_expression (reducing) of fat in fat
19) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.15 Pain Relevance 0
Given that the major reason given for not exercising is time [64], it is likely that the brevity of HIIE protocols should be appealing to most individuals interested in fat reduction.
Gene_expression (reduction) of fat in fat
20) Confidence 0.07 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2991639 Disease Relevance 0.34 Pain Relevance 0.06

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