INT169596

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.55
Pain Relevance 6.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
sensory neuron 2
IB4 2
macrophage 1
nociceptor 1
olfactory 1
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.8 10 100.00 Very High Very High Very High
nociceptor 274 99.66 Very High Very High Very High
dorsal root ganglion 220 98.76 Very High Very High Very High
Pain 62 97.28 Very High Very High Very High
gABA 2 96.68 Very High Very High Very High
Inflammation 102 96.12 Very High Very High Very High
5HT 1 95.80 Very High Very High Very High
Neuropathic pain 105 95.44 Very High Very High Very High
Somatostatin 3 94.96 High High
Neurotransmitter 9 94.04 High High
Disease Link Frequency Relevance Heat
Leukemia 10 100.00 Very High Very High Very High
Ganglion Cysts 368 98.76 Very High Very High Very High
Pain 70 97.28 Very High Very High Very High
INFLAMMATION 117 96.12 Very High Very High Very High
Neuropathic Pain 133 95.44 Very High Very High Very High
Neurodegenerative Disease 42 95.32 Very High Very High Very High
Targeted Disruption 158 90.52 High High
Nociception 53 89.56 High High
Inflammatory Pain 60 88.44 High High
Apoptosis 30 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microarray studies have shown decreased levels of Runx1 and Runx3 transcripts in the sensory neurons of Brn-3a-knokout mice [40,41].
Transcription (levels) of Runx1 in sensory neurons
1) Confidence 0.71 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.59 Pain Relevance 0.17
In this regard, the gene encoding the transcription factor Runx1 has emerged as a specific marker of restricted neuronal populations in the murine central and peripheral nervous systems.
Transcription (transcription) of Runx1 in peripheral nervous systems
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.16
IB4 is also distributed in both Runx1-persistent and Runx1-transient nociceptors.
Transcription (distributed) of Runx1-persistent in IB4 associated with nociceptor
3) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.19 Pain Relevance 1.12
IB4 is also distributed in both Runx1-persistent and Runx1-transient nociceptors.
Transcription (distributed) of Runx1 in IB4 associated with nociceptor
4) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.19 Pain Relevance 1.13
We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron phenotypes necessary for inflammatory and neuropathic pain.


Transcription (transcription) of Runx1 in sensory neuron associated with inflammation, nociceptor and neuropathic pain
5) Confidence 0.53 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2919460 Disease Relevance 0.52 Pain Relevance 0.86
Earlier in situ hybridization studies indicated strong expression of Runx1 mRNA in spinal motor neurons, DRG, cranial ganglia and specialized sensory epithelial structures such as olfactory and gustatory mucosa, and follicles of the vibrissae [20].
Transcription (expression) of Runx1 in olfactory associated with dorsal root ganglion
6) Confidence 0.53 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.85 Pain Relevance 0.24
The upstream signals and transcriptional regulation of RUNX genes have been studied in non-neuronal tissues [37].
Transcription (transcriptional) of RUNX in neuronal
7) Confidence 0.53 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.62 Pain Relevance 0.19
The mRNA expression and protein synthesis for Runx1/Runx3 are tightly regulated and DRG is one of the tissues in which Runx1/Runx3 display their highest protein levels among the entire body; how do DRG neurons achieve such a high protein level for Runx1/Runx3?
Transcription (expression) of Runx1 in body associated with dorsal root ganglion
8) Confidence 0.53 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.91 Pain Relevance 0.21
By contrast, nociceptor-associated mRNA transcripts (e.g., Nav1.8, P2xr3, and Runx-1) were downregulated, resulting in lower levels of protein and functional expression. qRT-PCR analysis also showed lowered levels of expression of nociceptor-specific pre-mRNA transcripts.
Transcription (transcripts) of Runx-1 in nociceptor associated with nociceptor and nav1.8
9) Confidence 0.51 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702715 Disease Relevance 0.53 Pain Relevance 1.43
Conserved decreases include the transcription factors Hmx1, Runx1 and basonuclin, the peptides galanin and PACAP, as well as advillin and latexin.
Transcription (transcription) of Runx1
10) Confidence 0.49 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.79 Pain Relevance 0.46
The finding that the transcription factor Runx1 is crucially involved in this process unfolds another essential issue.
Transcription (transcription) of Runx1
11) Confidence 0.40 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.31
During monocytic differentiation, the expression of these miRNAs is downregulated, whereas the transcription factor AML1 is upregulated at the protein but not mRNA level.
Transcription (transcription) of AML1
12) Confidence 0.12 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.15 Pain Relevance 0
Studies in human umbilical cord blood CD34+ haematopoietic progenitor cells induced to differentiate into monocytes upon exposure to macrophage-colony stimulating factor (M-CSF) showed that monocytopoiesis is controlled by a circuitry involving sequentially three miRNAs (i.e., miR-17-5p, miR-20a, and miR-106a, members of the miR-17–92 and related miR-106a–92 families) and the transcription factor acute myeloid leukaemia-1 (AML1) [128].
Transcription (transcription) of AML1 in macrophage associated with leukemia
13) Confidence 0.10 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.21 Pain Relevance 0

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