INT169597

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
sensory neurons 2
nociceptor 2
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.8 4 100.00 Very High Very High Very High
nociceptor 8 99.66 Very High Very High Very High
gABA 2 97.56 Very High Very High Very High
5HT 1 96.68 Very High Very High Very High
Somatostatin 3 95.84 Very High Very High Very High
Neurotransmitter 3 94.92 High High
trigeminal ganglion 67 90.68 High High
IPN 3 88.44 High High
dorsal root ganglion 55 87.44 High High
Spinal cord 14 85.20 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 35 91.40 High High
Ganglion Cysts 128 90.68 High High
Inflammatory Pain 3 88.44 High High
INFLAMMATION 1 79.16 Quite High
Pain 4 75.04 Quite High
Nociception 13 72.36 Quite High
Repression 7 23.16 Low Low
Neurodegenerative Disease 10 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microarray studies have shown decreased levels of Runx1 and Runx3 transcripts in the sensory neurons of Brn-3a-knokout mice [40,41].
Negative_regulation (decreased) of Transcription (levels) of Runx1 in sensory neurons
1) Confidence 0.58 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.59 Pain Relevance 0.17
By contrast, nociceptor-associated mRNA transcripts (e.g., Nav1.8, P2xr3, and Runx-1) were downregulated, resulting in lower levels of protein and functional expression. qRT-PCR analysis also showed lowered levels of expression of nociceptor-specific pre-mRNA transcripts.
Negative_regulation (downregulated) of Transcription (transcripts) of Runx-1 in nociceptor associated with nociceptor and nav1.8
2) Confidence 0.32 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702715 Disease Relevance 0.53 Pain Relevance 1.44
Conserved decreases include the transcription factors Hmx1, Runx1 and basonuclin, the peptides galanin and PACAP, as well as advillin and latexin.
Negative_regulation (decreases) of Transcription (transcription) of Runx1
3) Confidence 0.30 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.80 Pain Relevance 0.47

General Comments

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