INT169604

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.52
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) plasma membrane (Npr1)
intracellular (Npr1) nucleus (Nppb) cytoplasm (Nppb)
Anatomy Link Frequency
plasma 1
cardiac myocytes 1
Nppb (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 1 99.00 Very High Very High Very High
Pain 4 85.20 High High
dorsal root ganglion 3 76.48 Quite High
IPN 2 75.00 Quite High
Calcitonin gene-related peptide 3 62.80 Quite High
Glutamate 1 43.04 Quite Low
intrathecal 1 34.96 Quite Low
Thermal hyperalgesia 2 26.08 Quite Low
Inflammation 2 25.00 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 8 100.00 Very High Very High Very High
Ocular Hypertension 60 99.04 Very High Very High Very High
Fibrosis 1 99.00 Very High Very High Very High
Hypoxia 48 98.12 Very High Very High Very High
Pain 1 85.20 High High
Fatigue 2 84.04 Quite High
Pulmonary Hypertension 4 80.12 Quite High
Ganglion Cysts 3 75.52 Quite High
Nociception 3 75.00 Quite High
Inflammatory Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fernández-Durango showed that intracamerally injected BNP stimulated guanylate cyclase activity and decreased IOP.[16] Under chronic hypoxic conditions, plasma levels of BNP have been found to increase.[20] In addition to extended exposure to hypobaric hypoxia itself (10-91 days), endurance training in hypobaric hypoxic conditions leads to a marked early increase in ventricular and atrial BNP mRNA levels.[21] As for the physiologic effects that can be produced by elevated plasma BNP levels, Klinger et al., found that in rats, BNP infusion attenuated the development of hypoxic pulmonary hypertension.[22] The authors suggested that this finding supports the hypothesis that endogenous BNP plays a role in modulating the pulmonary hypertensive responses seen in chronic hypoxia.
BNP Positive_regulation (stimulated) of guanylate cyclase in plasma associated with pulmonary hypertension, hypoxia and ocular hypertension
1) Confidence 0.52 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2886248 Disease Relevance 1.76 Pain Relevance 0
B-type natriuretic peptide (BNP) has been known to be secreted from cardiac myocytes and activate its receptor, natriuretic peptide receptor-A (NPR-A), to reduce ventricular fibrosis.
BNP Positive_regulation (activate) of NPR-A in cardiac myocytes associated with natriuresis and fibrosis
2) Confidence 0.45 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.76 Pain Relevance 0.37

General Comments

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