INT169618

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (OGFR) cellular_component (OGFR) cytoplasm (OGFR)
Anatomy Link Frequency
brain 1
nucleus 1
OGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 54 91.36 High High
Enkephalin 4 90.28 High High
agonist 22 88.80 High High
antagonist 14 88.32 High High
methadone 135 81.80 Quite High
Morphine 18 75.52 Quite High
opioid receptor 37 62.48 Quite High
Potency 3 55.44 Quite High
Buprenorphine 88 50.00 Quite Low
Endogenous opioid 6 35.92 Quite Low
Disease Link Frequency Relevance Heat
Skin Cancer 2 98.48 Very High Very High Very High
Opiate Addiction 27 80.00 Quite High
Death 4 55.96 Quite High
Substance Withdrawal Syndrome 4 35.84 Quite Low
Drug Dependence 5 28.72 Quite Low
Recurrence 6 20.00 Low Low
Newborn Drug Withdrawal Syndrome 37 5.00 Very Low Very Low Very Low
Overdose 7 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A human squamous cell carcinoma of the head and neck cell line (squamous cell carcinoma-1, SCC-1) that was downregulated for karyopherin beta1 or Ran did not have transport of OGFr-eGFP into the nucleus.
Localization (transport) of OGFr-eGFP in nucleus associated with skin cancer
1) Confidence 0.72 Published 2010 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 20705629 Disease Relevance 0.20 Pain Relevance 0.21
Other studies have confirmed that OGFr localisation is associated with proliferating cells in the brain [174, 404, 442].
Localization (localisation) of OGFr in brain
2) Confidence 0.51 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647150 Disease Relevance 0.19 Pain Relevance 1.01

General Comments

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