INT169620

Context Info Confidence 0.55 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.46 Pain Relevance 0.28

extracellular region (SERPINB3) cytoplasm (SERPINB3)

Anatomy Link Frequency nucleus 1 SERPINB3 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 75.68 Opioid 2 75.00 Enkephalin 1 69.16 Inflammation 8 48.60 Serotonin 4 48.16 cytokine 5 5.00 chemokine 3 5.00 sodium channel 1 5.00 Pain 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Skin Cancer 2 99.92 Rupture 7 83.24 Stress 5 78.24 Disease 6 52.12 INFLAMMATION 6 48.60 Diverticulitis 21 39.00 Cancer 5 34.60 Colonic Diverticulosis 3 21.60 Acquired Immune Deficiency Syndrome Or Hiv Infection 48 17.64 Infection 33 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Short-circuit current (SCC) measured in ?

Localization (measured) of SCC

1) Confidence 0.55 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2064914 Disease Relevance 0.05 Pain Relevance 0

The authors found temporal changes in the expression of five proteins (serpin B3, serpin B1, annexin A3, collagen ?

Localization (collagen) of serpin B3

2) Confidence 0.31 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.21 Pain Relevance 0.07

A human squamous cell carcinoma of the head and neck cell line (squamous cell carcinoma-1, SCC-1) that was downregulated for karyopherin beta1 or Ran did not have transport of OGFr-eGFP into the nucleus.

Localization (transport) of SCC-1 in nucleus associated with skin cancer

3) Confidence 0.07 Published 2010 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 20705629 Disease Relevance 0.20 Pain Relevance 0.21

General Comments

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