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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.53
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SNCA) oxidoreductase activity (SNCA) cell death (SNCA)
extracellular region (SNCA) histone binding (SNCA) plasma membrane (SNCA)
Anatomy Link Frequency
neurons 1
SNCA (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 98.28 Very High Very High Very High
Substantia nigra 57 90.04 High High
midbrain 1 44.56 Quite Low
cINOD 1 38.40 Quite Low
Dopamine 29 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 62 98.24 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 23 97.76 Very High Very High Very High
Cognitive Disorder 15 97.16 Very High Very High Very High
Normal Pressure Hydrocephalus 1 97.16 Very High Very High Very High
Vascular Dementia 9 95.92 Very High Very High Very High
Disease 164 95.88 Very High Very High Very High
Frontotemporal Dementia 4 95.52 Very High Very High Very High
Parkinson's Disease 164 90.52 High High
Toxicity 13 79.44 Quite High
Infection 10 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We confirmed associations with SNCA and MAPT, replicated an association with GAK (using data from the NGRC and a previous study, P = 3.2 x 10(-9)) and detected a new association with the HLA region (using data from the NGRC only, P = 2.9 x 10(-8)), which replicated in two datasets (meta-analysis P = 1.9 x 10(-10)).
SNCA Binding (associations) of
1) Confidence 0.47 Published 2010 Journal Nat. Genet. Section Abstract Doc Link 20711177 Disease Relevance 0.42 Pain Relevance 0
-synuclein gene (SNCA) duplication, which in some instances is associated with somewhat more aggressive clinical presentation of both motor and cognitive symptoms [53], appears not to influence the ?
SNCA Binding (associated) of associated with cognitive disorder
2) Confidence 0.32 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 2.36 Pain Relevance 0
Aggregation of alpha-synuclein within the cytoplasm of TH-immunoreactive neurons is shown in Figure 1H and could be seen in most ?
alpha-synuclein Binding (Aggregation) of in neurons
3) Confidence 0.31 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2984491 Disease Relevance 0.20 Pain Relevance 0.36
The NACP has engaged the religious community in dialogue about the risks of HIV to Afghanistan and their role in community preventive education in a particularly noteworthy program.
NACP Binding (engaged) of associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.31 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC1262742 Disease Relevance 0.55 Pain Relevance 0

General Comments

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