INT16964

Context Info Confidence 0.48 First Reported 1991 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 27 Total Number 27 Disease Relevance 14.31 Pain Relevance 2.45

extracellular space (IFNG) extracellular region (IFNG)

Anatomy Link Frequency monocyte 2 body 2 anterior 1 dendritic cell 1 posterior 1 IFNG (Homo sapiens)

Pain Link Frequency Relevance Heat Anterior cingulate cortex 25 100.00 cytokine 88 99.96 tolerance 30 99.84 cINOD 2 99.12 Inflammation 54 97.32 Paracetamol 1 96.56 amygdala 18 93.76 tetrodotoxin 1 92.72 headache 10 91.48 cva 5 87.12

Disease Link Frequency Relevance Heat Endemic Invasive Fungal Infection 26 100.00 Cancer 20 100.00 Necrosis 7 100.00 Body Weight 9 99.88 Impaired Glucose Tolerance 36 99.84 Leukemia 2 99.58 INFLAMMATION 52 99.00 Injury 15 98.56 Appetite Loss 25 97.46 Diabetes Mellitus 719 97.20

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Event

Anatomy

Negation

Speculation

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Disease term

IFN-gamma interacts with cells by binding to specific membrane receptors.

IFN-gamma Binding (interacts) of

1) Confidence 0.48 Published 1994 Journal Acta Haematol Pol Section Abstract Doc Link 8209610 Disease Relevance 0.35 Pain Relevance 0.03

Recombinant gamma interferon (rHuIFN-gamma) has been recognized to increase mRNA and protein levels of C1 inhibitor (C1 INH) in various human cells.

Recombinant gamma interferon Binding (recognized) of

2) Confidence 0.45 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.33 Pain Relevance 0.06

Recombinant gamma interferon (rHuIFN-gamma) has been recognized to increase mRNA and protein levels of C1 inhibitor (C1 INH) in various human cells.

rHuIFN-gamma Binding (recognized) of

3) Confidence 0.45 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.33 Pain Relevance 0.06

In an open trial, longer courses of pentavalent antimonials (Sbv) at sub-optimal doses (10 mg/kg body weight), in association with recombinant human interferon-gamma (IFN-gamma) (100 micrograms/m2 of body surface area) were administered, by daily intramuscular injections, to 13 patients with diagnoses of cutaneous or mucocutaneous leishmaniasis unresponsive to Sbv.

interferon-gamma Binding (association) of in body associated with leishmaniasis and body weight

4) Confidence 0.37 Published 1994 Journal Trans. R. Soc. Trop. Med. Hyg. Section Abstract Doc Link 8154019 Disease Relevance 0.35 Pain Relevance 0

In an open trial, longer courses of pentavalent antimonials (Sbv) at sub-optimal doses (10 mg/kg body weight), in association with recombinant human interferon-gamma (IFN-gamma) (100 micrograms/m2 of body surface area) were administered, by daily intramuscular injections, to 13 patients with diagnoses of cutaneous or mucocutaneous leishmaniasis unresponsive to Sbv.

IFN-gamma Binding (association) of in body associated with leishmaniasis and body weight

5) Confidence 0.37 Published 1994 Journal Trans. R. Soc. Trop. Med. Hyg. Section Abstract Doc Link 8154019 Disease Relevance 0.35 Pain Relevance 0

Human blood monocytes (Mo) and monocyte-derived macrophages (M phi) are known to be potent antitumor cytotoxic effector cells through activation with recombinant human interferon gamma (rIFN-gamma), bacterial muramyldipeptide or the synthetic derivative muramyltripeptide phosphatidylethanolamine entrapped in liposomes (L-MTP-PE).

rIFN-gamma Binding (activation) of in monocyte

6) Confidence 0.37 Published 1991 Journal Int J Artif Organs Section Abstract Doc Link 1864656 Disease Relevance 0.16 Pain Relevance 0

For sIL-4, IFN-g, IFN-b and IFN-a no association with endothelial dysfunction was observed.

IFN-g Neg (no) Binding (association) of

7) Confidence 0.36 Published 2007 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2231343 Disease Relevance 0.89 Pain Relevance 0.23

IFN-gamma interacts with cells by binding to specific membrane receptors.

IFN-gamma Binding (binding) of

8) Confidence 0.35 Published 1994 Journal Acta Haematol Pol Section Abstract Doc Link 8209610 Disease Relevance 0.36 Pain Relevance 0.03

After completion or the IFN gamma 6-months treatment the patients continued with the corresponding chemotherapy schedule.

IFN gamma Binding (completion) of

9) Confidence 0.35 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC529257 Disease Relevance 0.70 Pain Relevance 0.19

The purpose of this study was to evaluate the levels of nitric oxide (NO), IL-4, TGF-beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in chronic periapical lesions and to determine their possible association with clinical and radiographic parameters.

interferon-gamma Binding (association) of associated with necrosis and cancer

10) Confidence 0.33 Published 2010 Journal J. Oral Pathol. Med. Section Abstract Doc Link 20102461 Disease Relevance 0.35 Pain Relevance 0.04

The purpose of this study was to evaluate the levels of nitric oxide (NO), IL-4, TGF-beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in chronic periapical lesions and to determine their possible association with clinical and radiographic parameters.

IFN-gamma Binding (association) of associated with necrosis and cancer

11) Confidence 0.33 Published 2010 Journal J. Oral Pathol. Med. Section Abstract Doc Link 20102461 Disease Relevance 0.35 Pain Relevance 0.04

Human blood monocytes (Mo) and monocyte-derived macrophages (M phi) are known to be potent antitumor cytotoxic effector cells through activation with recombinant human interferon gamma (rIFN-gamma), bacterial muramyldipeptide or the synthetic derivative muramyltripeptide phosphatidylethanolamine entrapped in liposomes (L-MTP-PE).

interferon gamma Binding (activation) of in monocyte

12) Confidence 0.32 Published 1991 Journal Int J Artif Organs Section Abstract Doc Link 1864656 Disease Relevance 0.16 Pain Relevance 0

During human negative valence scenes, compared with omnivores, vegetarians and vegans had an increased recruitment of the anterior cingulate cortex (ACC) and inferior frontal gyrus (IFG).

IFG Binding (recruitment) of in anterior associated with anterior cingulate cortex

13) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877098 Disease Relevance 0.09 Pain Relevance 0.21

To take into account reversibility of IFG, sensitivity analyses with persistent IFG as an end point were performed and showed a similar graded association between quartiles of carotenoids and dysglycemia (data not shown).

IFG Binding (association) of

14) Confidence 0.31 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2453670 Disease Relevance 0.16 Pain Relevance 0.04

This suggests that the left posterior MTG was functional, but did not interact with the left IFG during syntactic processing.

IFG Neg (not) Binding (d not in) of in posterior

15) Confidence 0.30 Published 2010 Journal Brain Section Body Doc Link PMC2965424 Disease Relevance 0 Pain Relevance 0

Within 1 month of injury, low interferon-gamma (IFN-gamma)-positive T cells (Th1) were found in association with low interleukin-12 (IL-12) and absent IFN-gamma cytokine levels in the serum.

IFN-gamma Binding (association) of in T cells associated with injury and cytokine

16) Confidence 0.29 Published 2006 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 16542140 Disease Relevance 1.66 Pain Relevance 0.32

Similarly G202R, a GC variant retained in the endoplasmic reticulum, is also shown to be amenable to chemical chaperoning.73 However, imino sugar derivatives are nonspecific and have relatively short half-lives in cells, and these molecules can inhibit other glycolipid and glycoprotein processing enzymes.74 Several studies have demonstrated that isofagomine (IFG), an imino sugar that binds to the active site, enhanced the folding, transport, and stability of several GC variants, including L444P.75 IFG was found to have little or no inhibitory activity against other glucosidases, and further treatment of wild type fibroblasts with high doses did not alter the processing of newly synthesized N-linked oligosaccharides.76 These findings supported the further evaluation of IFG as a potential therapeutic agent in GD.

IFG Binding (binds) of in fibroblasts associated with gauchers disease

17) Confidence 0.21 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.30 Pain Relevance 0

In this study, we have quantified the amount of immunoliposomes binding to IFN-gamma activated human bronchial epithelial cells (BEAS-2B) in vitro and studied the subsequent fate of cell-bound anti-ICAM-1 immunoliposomes.

IFN-gamma Binding (binding) of in BEAS-2B

18) Confidence 0.19 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.17 Pain Relevance 0.05

Cytokines are proposed to participate in the development and/or progression of cachexia-anorexia; interleukin-1, interleukin-6 (and its subfamily members such as ciliary neurotrophic factor and leukemia inhibitory factor), interferon-gamma, tumor necrosis factor-alpha, and brain-derived neurotrophic factor have been associated with various cachectic conditions.

interferon-gamma Binding (associated) of in ciliary associated with appetite loss, necrosis, leukemia, cancer and cytokine

19) Confidence 0.17 Published 2000 Journal Nutrition Section Abstract Doc Link 11054608 Disease Relevance 1.63 Pain Relevance 0.38

Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.

gamma-interferon Binding (interact) of associated with inflammation and cinod

20) Confidence 0.12 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9299399 Disease Relevance 0.66 Pain Relevance 0.18

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