INT169648

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 4.63
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) extracellular region (IGHG3) plasma membrane (AQP4)
transmembrane transport (AQP4) cytoplasm (AQP4)
Anatomy Link Frequency
M-1 2
IGHG3 (Homo sapiens)
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 24 97.56 Very High Very High Very High
Inflammation 4 93.40 High High
Multiple sclerosis 28 64.96 Quite High
Demyelination 14 35.84 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Sciatica 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 198 100.00 Very High Very High Very High
Transverse Myelitis 18 99.52 Very High Very High Very High
Optic Neuritis 22 97.56 Very High Very High Very High
Demyelinating Disease 56 96.04 Very High Very High Very High
INFLAMMATION 4 93.40 High High
Myasthenia Gravis 4 75.00 Quite High
Thymoma 2 75.00 Quite High
Syndrome 28 60.40 Quite High
Systemic Lupus Erythematosus 30 57.68 Quite High
Neurological Disease 18 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant proportion of NMO patients are seropositive for NMO-IgG, an autoantibody targeting aquaporin-4 (AQP4) water channel.
IgG Regulation (targeting) of aquaporin-4 associated with neuromyelitis optica
1) Confidence 0.02 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20728226 Disease Relevance 0.91 Pain Relevance 0.14
A significant proportion of NMO patients are seropositive for NMO-IgG, an autoantibody targeting aquaporin-4 (AQP4) water channel.
IgG Regulation (targeting) of AQP4 associated with neuromyelitis optica
2) Confidence 0.02 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20728226 Disease Relevance 0.91 Pain Relevance 0.14
Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform.


IgG Regulation (target) of AQP4 in M-1 associated with neuromyelitis optica
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 1.40 Pain Relevance 0.13
Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform.


IgG Regulation (target) of aquaporin-4 in M-1 associated with neuromyelitis optica
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 1.40 Pain Relevance 0.13

General Comments

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