INT169659

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.44
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav3) plasma membrane organization (Cav3) plasma membrane (Cav3)
enzyme binding (Cav3) protein complex (Cav3) cytoplasm (Cav3)
Anatomy Link Frequency
neuronal 2
oocytes 2
Cav3 (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.3 2 100.00 Very High Very High Very High
Opioid 15 99.64 Very High Very High Very High
ischemia 3 97.28 Very High Very High Very High
Calcium channel 14 97.16 Very High Very High Very High
narcan 9 96.60 Very High Very High Very High
antagonist 7 95.68 Very High Very High Very High
MU agonist 3 93.80 High High
Pyramidal cell 15 78.12 Quite High
fibrosis 22 76.04 Quite High
Glutamate 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 17 99.72 Very High Very High Very High
Coronary Artery Disease 3 97.72 Very High Very High Very High
Injury 3 97.32 Very High Very High Very High
Fibrosis 19 76.04 Quite High
Sprains And Strains 2 73.36 Quite High
Disease 6 50.00 Quite Low
Arrhythmias 2 Under Development 27 44.60 Quite Low
Heart Arrhythmia 16 8.48 Low Low
Aging 10 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a ?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Cav-3 associated with targeted disruption, coronary artery disease and ischemia
1) Confidence 0.70 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.35 Pain Relevance 0.63
Cav-3 overexpressing mice showed innate protection from I/R compared with controls that was abolished by naloxone.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Cav-3 associated with narcan
2) Confidence 0.50 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.38 Pain Relevance 0.71
Our results show that opioid-induced preconditioning is dependent on Cav-3 expression and that endogenous protection in Cav-3 overexpressing mice is opioid dependent.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Cav-3 associated with opioid
3) Confidence 0.50 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.34 Pain Relevance 0.69
Overexpression of the mRNA of neuronal Na+ channel, Nav1.3, and T-type Ca2+ channel, Cav3.2, may result from a feedback mechanism compensating for the larger conduction deficit of mice with a severe phenotype.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Cav3 in neuronal associated with nav1.3
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.19 Pain Relevance 0.17
We found that DHPG application upregulated barium currents in oocytes expressing mGluR5 and Cav2.3 but not mGluR5 and Cav3.2, suggesting subunit selective modulation of R-type, but not T-type, calcium channels by mGluR5 activation with DHPG (Figure 9C and 9D).
Positive_regulation (upregulated) of Neg (not) Gene_expression (expressing) of Cav3 in oocytes associated with calcium channel
5) Confidence 0.22 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.18 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox