INT169681

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 5.96
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Gmcl1)
Anatomy Link Frequency
GCL 3
retina 1
optic nerve 1
Gmcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Brush evoked pain 36 89.64 High High
COX2 35 85.76 High High
ketamine 5 63.44 Quite High
Inflammation 40 18.56 Low Low
Hyperesthesia 7 10.00 Low Low
Pain 15 5.00 Very Low Very Low Very Low
Spontaneous pain 5 5.00 Very Low Very Low Very Low
allodynia 5 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 431 99.88 Very High Very High Very High
Sprains And Strains 328 99.28 Very High Very High Very High
Ganglion Cysts 45 92.88 High High
Neuropathic Pain 57 89.64 High High
Ocular Toxicity (including Many Sub-types) 71 75.00 Quite High
Weight Loss 5 68.72 Quite High
Diabetic Retinopathy 66 68.12 Quite High
Peripheral Arterial Disease 5 57.12 Quite High
Hyperglycemia 55 45.84 Quite Low
INFLAMMATION 40 18.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of cells in the GCL was counted per 250 ?
Negative_regulation (number) of GCL in GCL
1) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927372 Disease Relevance 0.31 Pain Relevance 0.03
At four months of diabetes, the number of cells in the GCL was counted in retinal cross-sections through the optic nerve.
Negative_regulation (number) of GCL in optic nerve associated with diabetes mellitus
2) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927372 Disease Relevance 0.98 Pain Relevance 0
The statistical significance of this reduction in the Lewis strain was due to changes in the posterior retina only; none of the strains showed a statistically significant reduction in numbers of cells in the GCL in the mid-retina region (not shown).
Negative_regulation (reduction) of GCL in retina associated with sprains and strains
3) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927372 Disease Relevance 1.34 Pain Relevance 0
A significant loss of cells in the GCL occurred only in diabetic Lewis rats, whereas Wistar and Sprague Dawley rats showed little change.
Negative_regulation (loss) of GCL in GCL associated with diabetes mellitus
4) Confidence 0.19 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2927372 Disease Relevance 1.90 Pain Relevance 0.35
As summarized in Figure 2, only Lewis rats showed a significant reduction in the number of cells in the GCL compared to nondiabetic controls (p<0.05).
Negative_regulation (reduction) of GCL
5) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927372 Disease Relevance 1.16 Pain Relevance 0
A significant loss of cells in the GCL occurred only in diabetic Lewis rats, whereas Wistar and Sprague Dawley rats showed little change.
Negative_regulation (loss) of GCL in GCL
6) Confidence 0.19 Published 2010 Journal Mol. Vis. Section Body Doc Link 20806092 Disease Relevance 0.27 Pain Relevance 0

General Comments

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