INT169687

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 7.02
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 4
sensory neurons 2
Nerve 2
IB4 2
peripheral nervous system 2
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 60 99.80 Very High Very High Very High
Neuropathic pain 87 99.70 Very High Very High Very High
Peripheral nervous system 7 99.26 Very High Very High Very High
induced neuropathy 16 99.16 Very High Very High Very High
Morphine 83 97.76 Very High Very High Very High
allodynia 122 97.40 Very High Very High Very High
Pain 155 97.24 Very High Very High Very High
nociceptor 53 95.88 Very High Very High Very High
chronic construction injury 116 95.24 Very High Very High Very High
TRP channel 41 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 273 99.82 Very High Very High Very High
Neuropathic Pain 254 99.70 Very High Very High Very High
Hypersensitivity 110 99.30 Very High Very High Very High
Inflammatory Pain 18 99.00 Very High Very High Very High
Pain 130 97.24 Very High Very High Very High
Nervous System Injury 100 95.04 Very High Very High Very High
Ganglion Cysts 228 94.72 High High
INFLAMMATION 43 90.72 High High
Cancer 9 89.64 High High
Hyperalgesia 79 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding from experiments in genetically modified mice that menthol-induced cold hypersensitivity was not obviously influenced by TRPM8 expression but was dependent on TRPA1 expression was initially surprising.
Regulation (dependent) of Gene_expression (expression) of TRPA1 associated with hypersensitivity
1) Confidence 0.60 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.38 Pain Relevance 0.15
More importantly, we show that the shRNA and miRNA sequences targeting trpV1 have no effect on the expression levels of the closely related trpA1 gene or stat1, which is another gene involved in the INF response, when expressed in neurons in vivo.
Neg (no) Regulation (effect) of Gene_expression (expression) of trpA1 in neurons
2) Confidence 0.50 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.28 Pain Relevance 0.11
Transfection of TRPA1 in HEK293 cells did not significantly alter the proportion or magnitude of mechanically-activated currents in HEK293 cells, indicating that TRPA1 alone is not sufficient to confer mechanical sensitivity.These parallel genetic and pharmacological data demonstrate that TRPA1 mediates the Slowly Adapting mechanically-activated currents in small-diameter IB4 negative neurons from adult mice.
Neg (not) Regulation (alter) of Gene_expression (Transfection) of TRPA1 in IB4
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link 20808441 Disease Relevance 0.05 Pain Relevance 0.19
Again this could reflect a change in basal intracellular Ca2+ concentration in TRPA1 positive neurons during inflammatory pain.
Regulation (change) of Gene_expression (concentration) of TRPA1 in neurons associated with eae
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.04 Pain Relevance 0.53
This suggests that cold hypersensitivity in neuropathic pain is not always dependent upon increased expression of TRPA1 and TRPM8 in DRG.


Neg (not) Regulation (dependent) of Gene_expression (expression) of TRPA1 associated with hypersensitivity and neuropathic pain
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.68 Pain Relevance 0.29
Nerve-injury induced changes in the expression of TRPM8 and TRPA1
Regulation (changes) of Gene_expression (expression) of TRPA1 in Nerve associated with injury
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.27 Pain Relevance 0.92
To determine whether the neurotoxic effects on the peripheral nervous system from platinum drug exposure induces changes in the expression of TRPV1, TRPM8, and TRPA1 mRNA, we used a previously described cell culture model [50].
Spec (whether) Regulation (changes) of Gene_expression (expression) of TRPA1 mRNA in peripheral nervous system associated with peripheral nervous system
7) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.92 Pain Relevance 0.56
In this study, we used models of cisplatin and oxaliplatin-induced neuropathy to investigate whether TRPV1, TRPM8, and TRPA1 mRNA expression were altered along with changes in thermal sensitivity observed in chemotherapeutic neuropathy.
Spec (whether) Regulation (altered) of Gene_expression (expression) of TRPA1 mRNA associated with induced neuropathy and neuropathic pain
8) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.15 Pain Relevance 0.70
Our results indicate that injured sensory neurons do not develop abnormal cold sensitivity after chronic constriction injury and that alterations in the expression of TRPM8 and TRPA1 are unlikely to contribute directly to the pathogenesis of cold allodynia in this neuropathic pain model.



Regulation (alterations) of Gene_expression (expression) of TRPA1 in sensory neurons associated with allodynia, eae, injury and neuropathic pain
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2753652 Disease Relevance 0.99 Pain Relevance 0.66
A higher expression of TRPA1 and TRPV1 in visceral afferents [28,29] might contribute to the lower concentration of morphine required for activation of testicular nociceptors.
Regulation (afferents) of Gene_expression (expression) of TRPA1 in nociceptors associated with nociceptor and morphine
10) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0.24 Pain Relevance 1.63
In mice overexpressing GDNF or artemin, TRPA1 mRNA levels in DRG are increased indicating that different GFLs regulate TRPA1 expression.


Regulation (regulate) of Gene_expression (expression) of TRPA1
11) Confidence 0.16 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.19

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