INT16969

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 14.77
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Nucleus 3
nasal 2
lung 2
cortex 2
larynx 1
CRS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 7 100.00 Very High Very High Very High
adenocard 18 99.84 Very High Very High Very High
anesthesia 17 98.60 Very High Very High Very High
halothane 3 98.16 Very High Very High Very High
Central nervous system 2 92.68 High High
Inflammation 41 92.16 High High
Pain 10 91.52 High High
ischemia 7 90.36 High High
c fibre 4 90.28 High High
depression 16 83.36 Quite High
Disease Link Frequency Relevance Heat
Chronic Sinusitis 259 100.00 Very High Very High Very High
Rhinitis 82 100.00 Very High Very High Very High
Syndrome 65 100.00 Very High Very High Very High
Congenital Rubella Syndrome 11 100.00 Very High Very High Very High
Disease 130 99.12 Very High Very High Very High
Myocardial Infarction 43 99.12 Very High Very High Very High
Chronic Lymphoid Leukemia 147 98.48 Very High Very High Very High
Occupational Lung Diseases 2 98.40 Very High Very High Very High
Asthma 57 95.96 Very High Very High Very High
Sleep Disorders 2 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, we noted a significant decline in lung function after capsaicin CRS.
Negative_regulation (decline) of CRS in lung associated with qutenza
1) Confidence 0.37 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20134041 Disease Relevance 1.52 Pain Relevance 0.18
CRS with nasal polyps is considered to be a subgroup of CRS.
Negative_regulation (subgroup) of CRS in nasal associated with rhinitis and chronic sinusitis
2) Confidence 0.37 Published 2010 Journal Expert Rev Respir Med Section Abstract Doc Link 20658908 Disease Relevance 1.95 Pain Relevance 0.24
CRS with nasal polyps is considered to be a subgroup of CRS.
Negative_regulation (subgroup) of CRS in nasal associated with rhinitis and chronic sinusitis
3) Confidence 0.37 Published 2010 Journal Expert Rev Respir Med Section Abstract Doc Link 20658908 Disease Relevance 1.95 Pain Relevance 0.24
In addition it appears that this reduction in Crs can be reversed by paralyzing the child and manually ventilating with tidal volumes approximating those seen during sedation.
Negative_regulation (reduction) of Crs associated with sleep disorders
4) Confidence 0.29 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1864777 Disease Relevance 0.39 Pain Relevance 0.67
Fentanyl injection elicited an increase in Rrs (from 1.04 +/- 0.70 to 1.63 +/- 0.92 kPa x l-1 x s) and a further decrease in Crs (from 0.55 +/- 0.30 to 0.42 +/- 0.10 l x kPa-1) in the thiopental group but not in the propofol group (Rrs: 1.26 +/- 0.69 to 1.08 +/- 0.44 kPa x l-1 x s, Crs: 0.49 +/- 0.11 to 0.48 +/- 0.13 l x kPa-1).
Negative_regulation (decrease) of Crs
5) Confidence 0.27 Published 1990 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2343724 Disease Relevance 0.08 Pain Relevance 0
This pathway might be very attractive as a contemporary therapeutic target in CRS [14].
Negative_regulation (target) of CRS associated with syndrome
6) Confidence 0.25 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 1.10 Pain Relevance 0.23
In comparison with baseline, EELV, Crs, PaO2 were decreased and PaCO2 was increased after lung lavage as well as after lung lavage and injurious ventilation (Table 1).
Negative_regulation (decreased) of Crs in lung
7) Confidence 0.22 Published 2008 Journal Crit Care Section Body Doc Link PMC2374591 Disease Relevance 0 Pain Relevance 0
Compared with literature data the reduced overall dose of 20 Gy in 10 fractions led to a reduction of CRs by approximately 50% while the overall response rate remained equal.
Negative_regulation (reduction) of CRs
8) Confidence 0.22 Published 1997 Journal Acta Oncol Section Abstract Doc Link 9090967 Disease Relevance 0.62 Pain Relevance 0.15
For admission to the Cortex+Nucleus group, subjects must have satisfied the following criteria: (1) Both cortical and nuclear muscimol abolish CRs for at least one 10-trial block, and to ?
Negative_regulation (abolish) of CRs in Nucleus
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0 Pain Relevance 0
Likewise a nuclear cannula placement was considered on-target only if muscimol succeeded, but CNQX failed, to abolish CRs (demonstrating that muscimol was effective at inactivating nuclei without significantly spreading to cortex).
Neg (failed) Negative_regulation (abolish) of CRs in cortex
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0.06 Pain Relevance 0
CRs decline as CS parameters move away from the trained values.
Negative_regulation (decline) of CRs
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0 Pain Relevance 0.08
Subjects with a rapid (within 5 minutes) and complete block of CRs were deemed to have cortical infusion placements sufficiently close to the cortical eyeblink control regions that their muscimol infusions would have been cortically sufficient – with our without migration to the nuclei.
Negative_regulation (block) of CRs
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0 Pain Relevance 0.04
In the 4 subjects admitted to the Control group, cortical muscimol reduced CRs to 42.5±24.6% after 50 min, and to 10.8±10.8% at 2 hrs.
Negative_regulation (reduced) of CRs
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0.14 Pain Relevance 0.06
In the Cortex+Nucleus group, cortical CNQX abolished CRs within the first or the second 10-trial block (see Figure 4).
Negative_regulation (abolished) of CRs in Nucleus
14) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0 Pain Relevance 0
In the 4 subjects admitted to the Cortex+Nucleus group, cortical muscimol produced a rapid and prolonged loss of CR expression, with CRs reduced to 8.3±2.8% (mean ± SEM) at 50 min.
Negative_regulation (loss) of CRs in Nucleus
15) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0.16 Pain Relevance 0.07
A cortical cannula placement was considered on-target only if both muscimol and CNQX infusions produced a suitably rapid and profound abolition of CRs during Phase 5 Performance Testing (demonstrating that muscimol was effective at inactivating cortex within the temporal window vital for consolidation, but without significantly spreading to nuclei).
Negative_regulation (abolition) of CRs in cortex
16) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0.12 Pain Relevance 0
The Endo/Epi of IMP in IR was significantly decreased during CSO.
Negative_regulation (decreased) of CSO
17) Confidence 0.16 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11179085 Disease Relevance 0.22 Pain Relevance 0.15
These effects of CSO were partially abolished by adenosine.
Negative_regulation (abolished) of CSO associated with adenocard
18) Confidence 0.16 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11179085 Disease Relevance 0.24 Pain Relevance 0.17
The population chosen was peripubertal schoolgirls as the girls and women of this age group should be targeted when aim is to prevent CRS.
Negative_regulation (prevent) of CRS associated with congenital rubella syndrome
19) Confidence 0.09 Published 2010 Journal Indian Journal of Community Medicine : Official Publication of Indian Association of Preventive & Social Medicine Section Body Doc Link PMC2888342 Disease Relevance 1.81 Pain Relevance 0.05
Allergic rhinitis may have been present, but was unlikely to be a primary mechanism of CRS pathogenesis in these two categories.
Negative_regulation (mechanism) of CRS associated with rhinitis and chronic sinusitis
20) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1343550 Disease Relevance 0.92 Pain Relevance 0

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