INT169704

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.75
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
brush 4
endometrium 2
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 14 99.26 Very High Very High Very High
cytokine 36 88.64 High High
Calcium channel 24 86.84 High High
Inflammation 24 46.56 Quite Low
COX-2 inhibitor 2 25.68 Quite Low
TRP channel 2 17.76 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Celiac Disease 26 100.00 Very High Very High Very High
Dysmenorrhea 14 99.26 Very High Very High Very High
Adhesions 6 97.48 Very High Very High Very High
Congenital Anomalies 16 86.00 High High
Disease 5 71.40 Quite High
Pressure And Volume Under Development 6 66.40 Quite High
Frailty 6 65.04 Quite High
Toxicity 2 63.28 Quite High
Ulcers 2 56.04 Quite High
INFLAMMATION 36 46.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the epithelial component of adenomyotic lesions, vimentin expression was up-regulated and E-cadherin expression was down-regulated compared to the eutopic endometrium, suggesting that EMT occurs in adenomyosis.
Regulation (regulated) of Gene_expression (expression) of E-cadherin in endometrium associated with dismenorea
1) Confidence 0.35 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.94 Pain Relevance 0.87
In contrast, expression of E-cadherin RNA was markedly down regulated by 2.75 fold compared to non-sensitized mice, in gluten-sensitized plus indomethacin-treated mice.
Regulation (regulated) of Gene_expression (expression) of E-cadherin
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.06 Pain Relevance 0
E-cadherin expression is reduced in children with CD and gliadin has been shown to alter its expression [32].
Regulation (alter) of Gene_expression (expression) of E-cadherin associated with celiac disease
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.36 Pain Relevance 0
In our study, the expression of E-cadherin (pictures not shown) in the brush border of villi was not modified after FMSpH6 administration, which would indicate that the active components of the FMSpH6 act at different and specific levels, thus underlying the importance of the knowledge not only of the active constituents responsible for each effect but also of the target sites.
Regulation (modified) of Gene_expression (expression) of E-cadherin in brush
4) Confidence 0.05 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.26 Pain Relevance 0.07
The expression of E-cadherin in the brush-border membranes of the villi was not modified compared to control animals (pictures not shown).


Regulation (modified) of Gene_expression (expression) of E-cadherin in brush
5) Confidence 0.03 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.13 Pain Relevance 0.16

General Comments

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