INT169705

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 8.80
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
colon 3
small intestine 3
epithelium 2
endometrium 2
goblet cells 2
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 121 99.70 Very High Very High Very High
Dismenorea 14 98.98 Very High Very High Very High
Crohn's disease 63 98.36 Very High Very High Very High
cytokine 41 95.92 Very High Very High Very High
addiction 7 92.76 High High
cINOD 56 91.04 High High
Inflammation 75 85.64 High High
transdermal 8 72.28 Quite High
COX-2 inhibitor 3 21.20 Low Low
imagery 15 9.56 Low Low
Disease Link Frequency Relevance Heat
Celiac Disease 26 99.28 Very High Very High Very High
Cancer 328 98.98 Very High Very High Very High
Dysmenorrhea 14 98.98 Very High Very High Very High
Skin Cancer 21 98.92 Very High Very High Very High
Pathologic Processes 8 98.72 Very High Very High Very High
Disease 148 98.04 Very High Very High Very High
Inflammatory Bowel Disease 18 97.56 Very High Very High Very High
Apoptosis 91 97.36 Very High Very High Very High
Adhesions 27 95.24 Very High Very High Very High
Non-small-cell Lung Cancer 24 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of E-cadherin was reduced (Fig. 4C and D).
Negative_regulation (reduced) of Gene_expression (Expression) of E-cadherin
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.09 Pain Relevance 0
The stronger effect in colon was also true for the milder recombination protocol: In colon, expression of E-cadherin was almost completely lost, whereas in small intestine, expression was strongly reduced but not lost.
Negative_regulation (lost) of Gene_expression (expression) of E-cadherin in small intestine
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.33 Pain Relevance 0.05
Therefore, loss of E-cadherin expression is likely to result in the dissociation of Rac1 which may explain the disturbed maturation and positioning of Paneth and goblet cells observed.
Negative_regulation (loss) of Gene_expression (expression) of E-cadherin in goblet cells
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.15 Pain Relevance 0
Several studies have reported reduced expression of E-cadherin in inflamed epithelium of patients with Crohn's disease and ulcerative colitis [8]–[10].
Negative_regulation (reduced) of Gene_expression (expression) of E-cadherin in epithelium associated with inflammatory bowel disease, crohn's disease and disease
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.60 Pain Relevance 0.13
We report here that loss of E-cadherin expression results in loss of adherens junctions and desmosomes, leading to apoptosis and shedding of cells.
Negative_regulation (loss) of Gene_expression (expression) of E-cadherin associated with apoptosis
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.62 Pain Relevance 0.06
Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Negative_regulation (Impaired) of Gene_expression (expression) of E-cadherin in colon
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.28 Pain Relevance 0.04
In the epithelial component of adenomyotic lesions, vimentin expression was up-regulated and E-cadherin expression was down-regulated compared to the eutopic endometrium, suggesting that EMT occurs in adenomyosis.
Negative_regulation (down-regulated) of Gene_expression (expression) of E-cadherin in endometrium associated with dismenorea
7) Confidence 0.33 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.94 Pain Relevance 0.87
E-cadherin expression is reduced in children with CD and gliadin has been shown to alter its expression [32].
Negative_regulation (reduced) of Gene_expression (expression) of E-cadherin associated with celiac disease
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.36 Pain Relevance 0
Gluten-sensitized and indomethacin alone-treated mice showed reduced E-cadherin RNA expression by a mean factor of 0.762 and 0.533 respectively, but this did not achieve statistical difference relative to non-sensitized controls (Figure 4).
Negative_regulation (reduced) of Gene_expression (expression) of E-cadherin
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.06 Pain Relevance 0
Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function.
Negative_regulation (Impaired) of in small intestine Gene_expression (expression) of E-cadherin in colon
10) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001873 Disease Relevance 0.28 Pain Relevance 0.04
In addition, nicotine significantly reduced the expression of epithelial markers, E-Cadherin and ?
Negative_regulation (reduced) of Gene_expression (expression) of E-Cadherin associated with nicotine
11) Confidence 0.19 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759510 Disease Relevance 1.79 Pain Relevance 0.55
Furthermore, immunohistochemical staining of s.c. primary tumours of SPC-A-1sci cells also confirmed the remarkably reduced expression of E-cadherin (Fig. 2D).
Negative_regulation (reduced) of Gene_expression (expression) of E-cadherin associated with cancer
12) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.25 Pain Relevance 0
suppressors of E-cadherin expression.
Negative_regulation (suppressors) of Gene_expression (expression) of E-cadherin
13) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.62 Pain Relevance 0.05
There is decreased staining of E-cadherin and CD44 in situ compared with cultured cells.
Negative_regulation (decreased) of Gene_expression (staining) of E-cadherin
14) Confidence 0.07 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.00 Pain Relevance 0
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Negative_regulation (demonstrate) of Gene_expression (expression) of E-cadherin associated with cancer
15) Confidence 0.07 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.14 Pain Relevance 0
and LPS, are able to increase ADAM10 activity, leading to a loss in E-cadherin expression, which is another substrate for this secretase [68].
Negative_regulation (loss) of Gene_expression (expression) of E-cadherin
16) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.30 Pain Relevance 0.32

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