INT169710

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.27
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr35) plasma membrane (Gpr35) signal transducer activity (Gpr35)
Anatomy Link Frequency
plasma 4
spinal 1
bile 1
Gpr35 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 6 97.84 Very High Very High Very High
depression 77 94.64 High High
Inflammation 54 93.84 High High
nMDA receptor antagonist 6 91.52 High High
agonist 23 88.84 High High
midbrain 20 79.84 Quite High
Hippocampus 80 79.32 Quite High
Antinociceptive 2 75.00 Quite High
Serotonin 110 63.64 Quite High
cytokine 63 42.44 Quite Low
Disease Link Frequency Relevance Heat
Depression 83 99.08 Very High Very High Very High
Stress 489 99.00 Very High Very High Very High
Disease 41 96.72 Very High Very High Very High
Infection 73 95.88 Very High Very High Very High
Schizophrenia 23 95.36 Very High Very High Very High
INFLAMMATION 71 93.84 High High
Anxiety Disorder 157 93.68 High High
Disease Progression 6 91.36 High High
Frailty 6 89.52 High High
Lymphopenia 6 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their relatively low affinities for GPR35 and prominent off-target effects at other pathways, however, diminish their utility for understanding GPR35 signaling and for identifying potential therapeutic uses of GPR35.
Gene_expression (signaling) of GPR35
1) Confidence 0.67 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20826425 Disease Relevance 0 Pain Relevance 0.12
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Gene_expression (expressed) of Gpr35
2) Confidence 0.60 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.09
Both, peripheral blood and central spinal fluid (CSF) concentration of kynurenine seem to correlate with the levels of Quin and Kyna in the CSF predicting depressive symptoms in patients after IFN?
Gene_expression (levels) of Kyna in spinal associated with depression
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.78 Pain Relevance 0.22
Since Kyna can be produced by commensal bacteria and is found in pancreatic and bile juices [47], [48] formation of the molecule does not essentially dependent on IDO1 activity.
Gene_expression (produced) of Kyna in bile associated with bile
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.71 Pain Relevance 0.05
In addition, we found that in vivo ip Kyna injection dampened the LPS-induced TNF?
Gene_expression (injection) of Kyna
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.63 Pain Relevance 0
Kyna was injected ip at 250 ng/g BW and 6-h later TNF?
Gene_expression (injected) of Kyna
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.89 Pain Relevance 0
To our surprise, 1-MT treatment did not prevent that Kyna levels increased in repeatedly stress mice and it also did not reconstitute the inducibility of TNF?
Gene_expression (levels) of Kyna associated with stress
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.82 Pain Relevance 0.03
Thus, we hypothesize that peripherally increased Kyna concentration is a potent inhibitor of TNF?
Gene_expression (concentration) of Kyna
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.72 Pain Relevance 0.04
In chronological order based on the first publication, these include the GPR87 (Tabata et al., 2007; Wetter et al., 2009), P2Y5 (Pasternack et al., 2008; Shimomura et al., 2008), P2Y10 (Murakami et al., 2008) and GPR35 (Oka et al., 2010) gene products.
Gene_expression (products) of GPR35
9) Confidence 0.29 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
In contrast to our findings for Trp, plasma levels of Kyn and KYNA, which are downstream Trp metabolites generated by TDO (Figure 1), were sustained at physiological levels despite the absence of TDO.
Gene_expression (levels) of KYNA in plasma
10) Confidence 0.07 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.08
Although the mechanism remains unclear, our findings thus raise the possibility that Trp metabolism downstream of Kyn and KYNA plays a role in maintaining plasma Kyn and KYNA levels in Tdo-/- mice.
Gene_expression (levels) of KYNA in plasma
11) Confidence 0.06 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.30 Pain Relevance 0.04
This finding suggests the presence of compensatory mechanisms to maintain Kyn and KYNA levels in Tdo-/- mice; and given that IDO mediates the same metabolic processes as TDO in various tissues, it is the most likely candidate.
Gene_expression (levels) of KYNA
12) Confidence 0.06 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.07
Although the mechanism remains unclear, our findings thus raise the possibility that Trp metabolism downstream of Kyn and KYNA plays a role in maintaining plasma Kyn and KYNA levels in Tdo-/- mice.
Gene_expression (metabolism) of KYNA in plasma
13) Confidence 0.06 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.23 Pain Relevance 0.03
Plasma levels of Trp metabolites (Trp, Kyn, KYNA, ILA, IAA, 5-HT, and 5-HIAA) were determined using HPLC-FD and HPLC-UV systems as previously described [49].
Spec (determined) Gene_expression (levels) of KYNA in Plasma
14) Confidence 0.06 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0

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