INT169711

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.63
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr35) plasma membrane (Gpr35) signal transducer activity (Gpr35)
Anatomy Link Frequency
plasma 1
mononuclear cells 1
Gpr35 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor antagonist 8 98.64 Very High Very High Very High
depression 56 94.96 High High
Serotonin 120 93.28 High High
Bile 8 91.36 High High
Visceral pain 1 87.20 High High
Antinociceptive 2 84.00 Quite High
agonist 17 81.88 Quite High
antagonist 18 68.08 Quite High
cytokine 82 67.80 Quite High
Inflammation 57 67.44 Quite High
Disease Link Frequency Relevance Heat
Stress 624 99.40 Very High Very High Very High
Disease 31 96.72 Very High Very High Very High
Infection 95 95.88 Very High Very High Very High
Depression 64 94.96 High High
Frailty 8 94.84 High High
Schizophrenia 17 94.36 High High
Lymphopenia 8 93.64 High High
Disease Progression 8 91.36 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 87.48 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found that pamoic acid induces a G(i/o)-linked, GPR35-mediated increase in the phosphorylation of extracellular signal-regulated kinase 1/2, recruitment of ?
Positive_regulation (increase) of GPR35
1) Confidence 0.50 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20826425 Disease Relevance 0 Pain Relevance 0.36
Low-grade but significantly increased bacterial dissemination after intestinal barrier dysfunction [13], [37] may explain increased Kyna levels after repeated stress which may not be prevented by 1-MT treatment but is not investigated, yet.
Positive_regulation (increased) of Kyna associated with stress
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.70 Pain Relevance 0.05
In our study, we showed for the first time that activation of the Trp catabolism in BALB/c mice caused a peripheral accumulation of Kyna which is a (N-methyl-D-aspartat) NMDA receptor antagonist and is known to contribute to the development of disorders such as depression and schizophrenia [34].
Positive_regulation (accumulation) of Kyna associated with nmda receptor antagonist, depression and schizophrenia
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.75 Pain Relevance 0.20
secretion in human peripheral blood mononuclear cells via gpr35 activation [46].
Positive_regulation (activation) of gpr35 in mononuclear cells
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.74 Pain Relevance 0.04
inducibility in mouse splenocytes is also found after in vitro Kyna treatment which is demonstrated by preventing the LPS-induced TNF?
Positive_regulation (demonstrated) of Kyna
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.65 Pain Relevance 0
This indicates that the 1-MT treatment causes Kyna accumulation by a yet unknown pathway.
Positive_regulation (causes) of Kyna
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.61 Pain Relevance 0
To our surprise, 1-MT treatment did not prevent that Kyna levels increased in repeatedly stress mice and it also did not reconstitute the inducibility of TNF?
Positive_regulation (increased) of Kyna associated with stress
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.82 Pain Relevance 0.03
Thus, we hypothesize that peripherally increased Kyna concentration is a potent inhibitor of TNF?
Positive_regulation (increased) of Kyna
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.72 Pain Relevance 0.04
Preliminary data give evidence that ip injection of Kyn is followed by an increase of plasma Kyna levels within the next 30 minutes whereas peripheral Quin levels remain unaffected in BALB/c mice (Suppl.
Positive_regulation (increase) of Kyna in plasma
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.56 Pain Relevance 0.14
100 ┬ÁM activated GPR35.


Positive_regulation (activated) of GPR35
10) Confidence 0.20 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0

General Comments

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