INT169725

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.99
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6ra) extracellular region (Il6ra) enzyme binding (Il6ra)
Anatomy Link Frequency
joint 1
osteoblasts 1
muscle 1
Il6ra (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 99.36 Very High Very High Very High
cytokine 56 98.44 Very High Very High Very High
Inflammation 132 94.60 High High
Arthritis 15 85.28 High High
rheumatoid arthritis 3 75.00 Quite High
chemokine 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 99.36 Very High Very High Very High
Cervical Cancer 2 96.08 Very High Very High Very High
Hypercalcemia 18 95.72 Very High Very High Very High
Rheumatoid Arthritis 183 95.64 Very High Very High Very High
INFLAMMATION 135 94.60 High High
Disease 52 90.60 High High
Solid Tumor 3 90.28 High High
Cancer 80 85.76 High High
Arthritis 12 85.28 High High
Osteoporosis 27 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The chemically synthesized S7 peptide blocked the interaction between interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in a concentration-dependent manner, prevented IL-6-mediated survival signaling, and sensitized cervical cancer cells to chemotherapeutic compounds in vitro.
IL-6R Binding (interaction) of associated with cervical cancer
1) Confidence 0.07 Published 2006 Journal Int J Pept Res Ther Section Body Doc Link PMC2678933 Disease Relevance 0.78 Pain Relevance 0
Ci/ml of [3H] thymidine with IL-6, sIL-6-R, or both (100 ng/ml of each).
sIL-6-R Binding (thymidine) of
2) Confidence 0.04 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.11 Pain Relevance 0
However, the combination of sIL-6R and IL-6 markedly increased the inhibition, again suggesting a key role for IL-6 in causing joint damage in RA.


sIL-6R Binding (combination) of in joint associated with rheumatoid arthritis
3) Confidence 0.03 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 1.06 Pain Relevance 0.13
In an in vitro study, IL-6-induced osteoclast differentiation is indirect and appears to be mediated via interaction with osteoblasts through the sIL-6R, resulting in PGE2 synthesis.
sIL-6R Binding (interaction) of in osteoblasts
4) Confidence 0.03 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.76 Pain Relevance 0.15
Indeed, trans-signalling, where IL-6 binds to the sIL-6R, homodimerizes with glycoprotein 130 subunits and induces signal transduction, has been found to play a key role in acute and chronic inflammation.
sIL-6R Binding (binds) of associated with inflammation
5) Confidence 0.03 Published 2010 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2789585 Disease Relevance 0.99 Pain Relevance 0.22
Our data suggests an association between sIL-6R, perception of pain and reduced peak muscle performance post-EIMD but further investigation is warranted to explore this relationship and implications for exercise performance.
sIL-6R Binding (association) of in muscle associated with pain
6) Confidence 0.01 Published 2010 Journal Exerc Immunol Rev Section Abstract Doc Link 20839491 Disease Relevance 0.29 Pain Relevance 0.10

General Comments

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