INT169726

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.14
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6ra) extracellular region (Il6ra) enzyme binding (Il6ra)
Anatomy Link Frequency
articular 1
Plasma 1
leukocyte 1
Il6ra (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 99 89.96 High High
cytokine 39 85.44 High High
Pain 6 77.84 Quite High
abatacept 3 64.24 Quite High
rheumatoid arthritis 3 50.00 Quite Low
Inflammatory mediators 6 49.60 Quite Low
Arthritis 15 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 3 99.88 Very High Very High Very High
Rheumatoid Arthritis 183 99.16 Very High Very High Very High
Myalgia 6 93.76 High High
INFLAMMATION 102 89.96 High High
Autoimmune Disease 9 87.12 High High
Osteoporosis 27 85.12 High High
Acute Coronary Syndrome 3 84.60 Quite High
Fatigue 30 83.16 Quite High
Anaemia 27 81.36 Quite High
Pain 2 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6R inhibition in the treatment of RA
Negative_regulation (inhibition) of IL-6R associated with rheumatoid arthritis
1) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.68 Pain Relevance 0.09
The combination of articular and systemic effects of IL-6 makes inhibition of the IL-6R a logical target for treatment of patients with RA.
Negative_regulation (inhibition) of IL-6R in articular associated with rheumatoid arthritis
2) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.93 Pain Relevance 0.17
This observation is supported by Phase III studies using an anti-IL-6R antibody, which have demonstrated benefits of IL-6R inhibition across a number of patient populations with RA.



Negative_regulation (inhibition) of IL-6R associated with rheumatoid arthritis
3) Confidence 0.03 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.93 Pain Relevance 0.13
Our novel finding that sIL-6R concentrations are decreased 2-3 days following a single bout of EIMD may reflect a regulatory mechanism controlling the influx of different leukocyte subpopulations into damaged tissue, although this needs to be confirmed by future studies.
Negative_regulation (decreased) of sIL-6R in leukocyte
4) Confidence 0.01 Published 2010 Journal Exerc Immunol Rev Section Abstract Doc Link 20839491 Disease Relevance 0.30 Pain Relevance 0.08
Plasma IL-6 and sgp130 were unchanged at any time point during recovery but sIL-6R was significantly reduced at 48 h and 72 h post-exercise (p < 0.05).
Negative_regulation (reduced) of sIL-6R in Plasma
5) Confidence 0.01 Published 2010 Journal Exerc Immunol Rev Section Abstract Doc Link 20839491 Disease Relevance 0.30 Pain Relevance 0.05

General Comments

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